Compositions and methods for a multi-adjuvant only approach to immunoprophylaxis for preventing infections
This disclosure provides a new vaccine composition and methods for its use. The composition contains an effective amount of each of: an aluminum hydroxide, a mono-phosphoryl lipid (MPL), and a whole glucan particles (WGP) but no an antigen that raises an immune response against a bacterial or fungal infection.
1. A composition consisting essentially of an effective amount of each of aluminum hydroxide, mono-phosphoryl lipid (MPL), and whole glucan particles (WGP) with the proviso that the composition does not comprise an antigen effective to induce an immune response against a fungus or a bacterium.
2. A composition consisting essentially of an effective amount of each of aluminum hydroxide, mono-phosphoryl lipid (MPL), whole glucan particles (WGP), and mannan with the proviso that the composition does not comprise an antigen effective to induce an immune response against a fungus or a bacterium.
3. The composition of claim 1 , wherein the effective amount of the aluminum hydroxide is from 0.1 to 10 mg/ml and the effective amount of the MPL is from 0.1 to 10 mg/ml, and are combined in a ratio of from 1:1 to 1:20 for the aluminum hydroxide and the MPL to the WGP.
4. The composition of claim 2 , wherein the effective amount of the aluminum hydroxide is from 0.1 to 10 mg/ml and the effective amount of the MPL is from 0.1 to 10 mg/ml of the MPL, and are combined in a ratio of from 1:1 to 1:20 for the aluminum hydroxide and the MPL to the WGP, and wherein the effective amount of the mannan is from 0.01 mg/ml to 1 mg/ml.
5. The composition of claim 2 , wherein the effective amount of the mannan is from 0.01 mg/ml to 1 mg/ml.
6. A kit comprising the composition of claim 1 or claim 2 and instructions for use.
7. A method to augment innate immunity against a bacterium or a fungus in a mammalian subject comprising administering to the subject an effective amount of the composition of claim 1 or claim 2 .
8. The method of claim 7 , wherein the bacterium is selected from S. aureus, A. baumannii, K. pneumoniae, P. aeruginosa, E. coli, Enterobacter spp., Serratia, Stenotrophomonas , and the fungus is Candida spp.
9. The method of claim 7 , wherein the subject is at risk of a bacterial infection or a fungal infection.
10. The method of claim 7 , wherein the subject is infected with the bacterium or the fungus.