Uses of lipophenolic compounds
The present invention relates to compound of formula (I): wherein R is O—R 3 or R 1 and R 2 are identical or different and are each independently H, (C 1 -C 6 )alkyl, —CO—(C 1 -C 21 )alkyl or —CO—(C 11 -C 21 )alkenyl group, provided that at least one of R 1 or R 2 is H or (C 1 -C 6 )alkyl, R 3 is a —CO—(C 11 -C 21 )alkyl or —CO—(C 11 -C 21 )alkenyl group, or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof, for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability.
1. A method for the treatment of encephalitis comprising administering, to a person in need thereof, a compound of formula (IIb):
with R 3 selected from the group consisting of:
or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof.
2. The method of claim 1 , wherein the compound is administered for 1 to 4 days, and just before and/or during the acute phase response associated with factors inducing the increased vascular, lymphatic or mucosal permeability.
3. The method of claim 1 , wherein the compound of formula (IIb) is administered in association with at least one additional active compound selected from the group consisting of antibiotic, antiviral, antifungal, antiparasitic, anti-inflammatory active compound and mixtures thereof.