Catheter lock solution comprising sodium citrate and benzyl alcohol
This disclosure generally relates to catheters, methods of enhancing the patency of an intravascular catheter and compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Disclosed compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A representative lock solution includes about 10% sodium citrate and about 1.5% benzyl alcohol. The solution has a density approximating the density of blood for retention of the solution in a catheter during the lock period.
1. An aqueous antimicrobial solution comprising about a synergistic combination of about 7% by weight citrate and about 1.5% by weight benzyl alcohol dispersed or dissolved therein.
2. The solution of claim 1 , wherein the citrate is trisodium citrate dihydrate.
3. The solution of claim 1 , wherein the pH of the solution is from about 5 to about 7.5.
4. The solution of claim 1 , wherein the relative density of the solution is from about 1.030 to about 1.060 g/ml.
5. The solution of claim 1 , wherein the solution further comprises a viscosifying agent.
6. A catheter lock solution to prevent clotting of central venous catheters and to kill bacteria contaminating the interior lumen of the catheters comprising:
the aqueous antimicrobial solution of claim 1 .
7. The solution of claim 6 , in which the pH is adjusted to a range of about 6.0 to about 6.5 by addition of citric acid or other form of acid.
8. A method to prevent clotting of central venous catheters and to kill bacteria contaminating the interior lumen of the catheters using the catheter lock solution of claim 6 .
9. A method of inhibiting infection in an indwelling catheter defining at least one lumen therethrough, the method comprising infusing an aqueous catheter lock solution into a lumen of the catheter, the solution comprising a catheter lock solution of claim 6 .
10. The method of claim 9 wherein the catheter is an intravascular catheter or a body cavity catheter.
11. The method of claim 9 wherein the lumen of the catheter has an internal volume and the method comprises infusing an amount of the lock solution that is from about 80% to about 120% of the internal volume of the lumen.
12. The method according to claim 9 wherein the citrate is trisodium citrate dihydrate.
13. The method of according to claim 9 wherein the pH of the solution is from about 5 to about 7.5.
14. The method according to claim 9 wherein the relative density of the solution is from about 1.030 to about 1.060 g/ml.
15. The method according to claim 9 wherein the solution further comprises a viscosifying agent.
16. The method according to claim 9 , wherein the catheter is in a patient.
17. The method according to claim 16 , wherein the catheter is surgically implanted.