Composition of a calcium phosphate and an additive compound containing a phosphate or phosphonate group
The present invention relates to a composition of a calcium phosphate such as tetracalcium phosphate or α-TCP and an additive compound selected from nucleic acid or nucleotides, phospho(enol)pyruvic acid and phosphocreatine. The composition may be used as a tissue adhesive.
1. An aqueous composition comprising:
a. an aqueous solution;
b. a calcium phosphate compound wherein the calcium phosphate is α-TCP;
c. an additive compound selected from phosphocreatine, wherein the carboxylic acid of the phosphocreatine may be in acid form or the corresponding salt;
wherein the calcium phosphate compound represents 10-90 wt % and the additive compound represents 10-90 wt % of the solid content in the composition,
wherein the composition comprises an acid, said acid optionally being the carboxylic acid of the additive compound, and has an acid concentration of 1.0-4.0M, and
wherein the liquid/powder (L/P) ratio is 0.16-0.45.
2. The aqueous composition according to claim 1 , wherein the composition further comprises an accelerator or retardant which is sodium citrate.
3. The aqueous composition according to claim 1 , wherein the amount of the additive compound is 25-75 wt %.
4. The aqueous composition according to claim 1 , wherein the L/P ratio is 0.20-0.35.
5. A biological tissue adhesive comprising the composition according to claim 1 .
6. A bone filler comprising the composition according to claim 1 .
7. A dental implant comprising the composition according to claim 1 .
8. A method of adhering a first tissue to a second surface using the tissue adhesive according to claim 5 comprising:
a. applying the tissue adhesive according to claim 5 to the first tissue or to the second surface and optionally leave it for a period of time of about 20 seconds to about 60 seconds;
b. bringing the first tissue and the second surface into contact with each other;
c. optionally applying a pressure on the first and second tissue for a period of time of about 1 to about 3 minutes; and
d. letting the tissue adhesive cure.
9. A kit for preparing the composition according to claim 1 comprising at least two containers wherein any one container in the kit can contain any of the aqueous solution, the additive compound, the calcium phosphate compound or a combination thereof, with the proviso that both the additive compound and the calcium phosphate compound cannot be present in the same container as the aqueous solution; and
wherein the amount of aqueous solution, additive compound, calcium phosphate compound in the containers is such that when mixed the composition according to claim 1 is obtained.
10. The aqueous composition according to claim 1 wherein the L/P ratio is 0.20-0.30.
11. The aqueous composition according to claim 2 , wherein the sodium citrate is in the range of 5-66% weight/volume.