Method for preparing salicylamine acetate

1. A method for preparing salicylamine acetate, wherein the method comprises steps of:

(1) subjecting salicylaldehyde of Structural Formula 1:

to amino protection to obtain a compound of Structural Formula 2:

wherein the amino protection is performed with equivalent ratio of tert-butyl carbamate to salicylaldehyde of 1.0-3.0: 1;

and

(2) subjecting the compound of Structural Formula 2 to acid hydrolysis, followed by reaction with acetic acid to obtain salicylamine acetate.

2. The method of claim 1 , wherein the amino protection in Step (1) is performed at a reaction temperature of 0-50° C.

3. The method of claim 1 , wherein the amino protection in Step (1) is performed for a reaction time of 3-18 hours.

4. The method of claim 1 , wherein a reaction solvent selected from the group consisting of tetrahydrofuran, 2-methyltetrahydrofuran, acetonitrile and 1,4-dioxane is used in Step (1).

5. The method of claim 1 , wherein an acid selected from the group consisting of hydrochloric acid, trifluoroacetic acid, hydrobromic acid and sulfuric acid is used for the hydrolysis in Step (2).

6. The method of claim 1 , wherein the acid hydrolysis in Step (2) is performed in the presence of an alcoholic organic solvent.

7. The method of claim 6 , wherein the alcoholic organic solvent is a C1-4 aliphatic alcohol.

8. The method of claim 1 , wherein the reaction with acetic acid in Step (2) is performed at a temperature ranging from room temperature to the reflux temperature of the acetic acid solution.

9. The method of claim 1 , wherein the reaction with acetic acid in Step (2) is performed for a reaction time of 10-24 hours.

10. The method of claim 6 , wherein the alcoholic organic solvent is selected from methanol, ethanol, and n-butanol.