IP Library › Granted Patent US 12,453,477
Granted Patent B2
US 12,453,477 · App. 16/772,644 · Granted Oct 28, 2025

Endoscopic imaging using nanoscale metasurfaces

Inventors: Hamid Pahlevaninezhad (Cambridge, MA); Mohammadreza Khorasaninejad (Cambridge, MA); Yao-Wei Huang (Cambridge, MA); Zhujun Shi (Cambridge, MA); Melissa Suter (Cambridge, MA); Federico Capasso (Cambridge, MA)
Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION; PARTNERS HEALTHCARE
A61B5/0097A61B1/00096A61B1/00188A61B1/07A61B5/0066A61B5/0068G01B9/02001G01B9/02091G02B1/002G02B3/0087G02B23/243G02B27/0025A61B1/00165G02B2207/101
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,453,477
App. No.
16/772,644
Granted
Oct 28, 2025
Kind
B2
Abstract

An endoscopic imaging device (e.g., a catheter) comprises a light-transmitting tubing, at least one optical fiber disposed in the light-transmitting tubing, and at least one metalens. The metalens is optically coupled to the optical fiber and is configured to focus light from the optical fiber, through the light-transmitting tubing, and to a target point located outside of the light-transmitting tubing. The metalens includes a plurality of nanostructures. The nanostructures define a phase profile that corrects astigmatism caused by the light-transmitting tubing.

Claims (56)

1. An endoscopic imaging device, comprising:

a light-transmitting tubing;

at least one optical fiber disposed in the light-transmitting tubing; and

at least one metalens optically coupled to the optical fiber and configured to:

receive light from the optical fiber;

transmit the light through the at least one metalens; and

focus the light from the optical fiber, through the light-transmitting tubing, and to a target point located outside of the light-transmitting tubing;

wherein the metalens includes a plurality of nanostructures, and the nanostructures define a phase profile that corrects one or more aberrations including astigmatism caused by the light-transmitting tubing;

wherein the phase profile corrects the one or more aberrations by focusing the light from the optical fiber to a diffraction-limited spot; and

wherein the phase profile, φ, is a function of L sl which is an optical path length between a facet of the optical fiber and the metalens, L lf which is an optical path length between the metalens and a focal point of the metalens, and L chief which is an optical path length of a chief ray.

2. The endoscopic imaging device of claim 1 , wherein the metalens is further configured to collect light from the target point outside of the light-transmitting tubing, through the light-transmitting tubing, and to the optical fiber.

3. The endoscopic imaging device of claim 1 , wherein the phase profile of the nanostructures corrects one or more aberrations including astigmatism caused by tubing curvatures of the light-transmitting tubing parallel or perpendicular to a catheter axis.

4. The endoscopic imaging device of claim 1 , wherein the phase profile of the nanostructures compensates length differences between a shortest optical path between the target point and the focal point of the metalens and an optical path between the target point and the focal point of the metalens.

5. The endoscopic imaging device of claim 1 , further comprising a prism optically coupling the metalens to the optical fiber.

6. The endoscopic imaging device of claim 1 , wherein the nanostructures comprise amorphous silicon nanopillars having an azimuthal symmetry.

7. The endoscopic imaging device of claim 1 , wherein the nanostructures have a common height and various diameters and the phase profile depends on the diameters of the nanostructures.

8. The endoscopic imaging device of claim 1 , wherein the nanostructures have a common height and various bases and the phase profile depends on the geometry of the nanostructures.

9. The endoscopic imaging device of claim 1 , wherein the metalens is configured to output light with a specific polarization state.

10. The endoscopic imaging device of claim 1 , wherein the metalens is configured to collect light with a specific polarization state.

11. The endoscopic imaging device of claim 1 , wherein the endoscopic imaging device is a catheter of an endoscopic optical coherence tomography system, a confocal endomicroscope, or a two-photon imaging endoscope.

12. The endoscopic imaging device of claim 1 , wherein the endoscopic imaging device is configured to extend an imaging depth-of-focus by modifying metalens dispersion.

13. An endoscopic imaging system, comprising:

an interferometer;

a detection unit coupled to the interferometer;

a catheter coupled to the interferometer, the catheter comprising:

a light-transmitting tubing;

an optical fiber disposed in the light-transmitting tubing; and

a metalens optically coupled to the optical fiber and configured to:

receive light from the optical fiber;

transmit the light through the metalens; and

focus the light from the optical fiber, through the light-transmitting tubing, and to a target point located outside of the light-transmitting tubing;

wherein the metalens includes a plurality of nanostructures, and the nanostructures define a phase profile that corrects astigmatism caused by the light-transmitting tubing;

wherein the phase profile corrects one or more aberrations by focusing the light from the optical fiber to a diffraction-limited spot; and

wherein the phase profile, φ, is a function of L sl which is an optical path length between a facet of the optical fiber and the metalens, L lf which is an optical path length between the metalens and a focal point of the metalens, and L chief which is an optical path length of a chief ray.

14. The endoscopic imaging system of claim 13 , wherein the phase profile of the nanostructures corrects astigmatism caused by tubing curvatures of the light-transmitting tubing parallel or perpendicular to a catheter axis.

15. The endoscopic imaging system of claim 13 , wherein the nanostructures comprise amorphous silicon nanopillars, and the phase profile depends on various diameters of the nanopillars.

16. The endoscopic imaging system of claim 13 , further comprising a fiber optic rotary joint coupling the catheter to the interferometer, the fiber optic rotary joint configured to control rotational and translational motions of the catheter.

17. The endoscopic imaging system of claim 13 , further comprising an acousto-optic optical modulator configured to control a depth degeneracy of the catheter.

18. The endoscopic imaging system of claim 13 , wherein the detection unit comprises at least one beam splitter and at least one balance detector.

19. The endoscopic imaging system of claim 13 , further comprising a wavelength-swept source coupled to the interferometer.

20. A polarization-sensitive optic endoscopic system, comprising:

a first optical fiber;

a second optical fiber; and

a catheter coupled to the first optical fiber and the second optical fiber, the catheter comprising:

a light-transmitting tubing, wherein a portion of the first optical fiber and a portion of the second optical fiber are disposed in the light-transmitting tubing;

a first metalens optically coupled to the first optical fiber and configured to focus light of a first polarization state from the first optical fiber and to a target point located outside of the light-transmitting tubing; and

a second metalens optically coupled to the second optical fiber and configured to focus light of a second polarization state from the second optical fiber and to the target point located outside of the light-transmitting tubing,

wherein the first metalens includes a plurality of first nanostructures, and the first nanostructures define a phase profile that focuses the light of the first polarization state to the target point;

wherein the phase profile corrects one or more aberrations by focusing the light from the first optical fiber to a diffraction-limited spot; and

wherein the phase profile, φ, is a function of L sl which is an optical path length between a facet of the first optical fiber and the first metalens, L lf which is an optical path length between the first metalens and a focal point of the metalens, and L chief which is an optical path length of a chief ray; and

wherein the second metalens includes a plurality of second nanostructures, and the second nanostructures define a phase profile that focuses the light of the second polarization state to the target point.

21. The polarization-sensitive optic endoscopic system of claim 20 , further comprising a multiple-channel interferometer configured to introduce optical path delays for multiple channels.

22. The polarization-sensitive optic endoscopic system of claim 20 , further comprising a frequency shifting component configured to provide acousto-optic frequency shifts for multiple channels.

23. The polarization-sensitive optic endoscopic system of claim 20 , wherein the first metalens is further configured to collect light of the first polarization state from the target point outside of the light-transmitting tubing and to the first optical fiber.

24. The polarization-sensitive optic endoscopic system of claim 20 , wherein the second metalens is further configured to collect light of the second polarization state from the target point outside of the light-transmitting tubing and to the second optical fiber.

25. The polarization-sensitive optic endoscopic system of claim 20 , wherein the first polarization state is a right-handed elliptical polarization state, and the second polarization state is a left-handed elliptical polarization state.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 16, 2020
From: CAPASSO, FEDERICO; HUANG, YAO-WEI; KHORASANMEJAD, MOHAMMEDREZA; SHI, ZHUJUN
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 054075/0099 →
Continuity (2)
Provisional Application 62598455 · Dec 13, 2017
Related Publication 20210068665A1 · Mar 11, 2021
References Cited (13)
US 7023558B2 · Fee · 2006 [cited by examiner]
US 20020131139A1 · Mandella · 2002 [cited by examiner]
US 20030001071A1 · Mandella · 2003 [cited by examiner]
US 20100165134A1 · Dowski, Jr. · 2010 [cited by examiner]
US 20160228071A1 · Wang · 2016 [cited by examiner]
US 20160299170A1 · Ito · 2016 [cited by examiner]
US 20170045652A1 · Arbabi et al. · 2017 [cited by applicant]
US 20170212285A1 · Arbabi · 2017 [cited by examiner]
US 20170224286A1 · Sakamoto · 2017 [cited by examiner]
WO WO2017176921A1 · 2017 [cited by applicant]
Khorasaninejad et al. 2016 Science 352 1190-1194 with supplemental materials pub.date Jun. 2016 (Year: 2016). [cited by examiner]
Ozdemir et al. 2017 Optics Comm. 401:46-53 ePub May 26, 2017 (Year: 2017). [cited by examiner]
International Search Report and Written Opinion for corresponding International Patent Application No. PCT/US2018/65288, 9 pages. [cited by applicant]