IP Library Granted Patent US 11,279,688
Granted Patent B2
US 11,279,688 · App. 16/775,646 · Granted Mar 22, 2022

Inhibitors of RET

Inventors: Jason D. Brubaker (Cambridge, MA); Joseph L. Kim (Wayland, MA); Kevin J. Wilson (Boston, MA); Douglas Wilson (Ayer, MA); Lucian V. DiPietro (Gloucester, MA)
Assignee: BLUEPRINT MEDICINES CORPORATION
C07D401/14C07D239/30C07D239/36C07D403/14
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Quick Facts
Patent No.
US 11,279,688
App. No.
16/775,646
Filed
Jan 29, 2020
Granted
Mar 22, 2022
Kind
B2
Art Unit
1624
USPC
514/275
Abstract

Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Claims (2)

1. A compound which is:

2. A compound which is:

Assignments (8)
SECURITY INTEREST Recorded May 8, 2026
From: RIGEL PHARMACEUTICALS, INC.
To: MIDCAP FUNDING IV TRUST
Reel/Frame 075576/0880 →
RELEASE OF SECURITY INTEREST (REEL/FRAME NUMBER 060616/0923) Recorded Jul 23, 2025
From: TAO TALENTS, LLC
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 072193/0847 →
SECURITY INTEREST Recorded May 23, 2024
From: RIGEL PHARMACEUTICALS, INC.
To: MIDCAP FINANCIAL TRUST
Reel/Frame 067509/0146 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 8, 2024
From: BLUEPRINT MEDICINES CORPORATION
To: RIGEL PHARMACEUTICALS, INC.
Reel/Frame 066703/0974 →
RELEASE OF SECURITY INTEREST Recorded Feb 22, 2024
From: TAO TALENTS, LLC, AS ADMINISTRATIVE AGENT
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 066536/0717 →
SECURITY INTEREST Recorded Jul 8, 2022
From: BLUEPRINT MEDICINES CORPORATION
To: TAO TALENTS, LLC
Reel/Frame 060616/0923 →
ASSIGNEE CHANGE OF ADDRESS Recorded Oct 13, 2021
From: BLUEPRINT MEDICINES CORPORATION
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 057789/0683 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 13, 2021
From: BRUBAKER, JASON D.; KIM, JOSEPH L.; WILSON, KEVIN J.; WILSON, DOUGLAS; DIPIETRO, LUCIAN V.
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 057789/0758 →
Continuity (5)
Continuation 16041719 · Jul 20, 2018
Continuation 15340428 · Nov 1, 2016
Provisional Application 62367960 · Jul 28, 2016
Provisional Application 62249784 · Nov 2, 2015
Related Publication 20200407341A1 · Dec 31, 2020
Cited By (4)
US 12,448,366 US 12,539,303 US 12,655,128 US 12,692,251