Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that selectively recognize cells that present a peptide consisting of the amino acid sequence of QYQNVLTLW (SEQ ID NO: 31), wherein the cancer is selected from lung cancer, brain cancer (GBM), gastric cancer (GC), hepatocellular carcinoma (HCC), melanoma (MEL), non-Hodgkin lymphoma (NHL), prostate cancer and benign prostate hyperplasia (PRCA), renal cell carcinoma (RCC), and uterine cancer (UEC).
2. The method of claim 1 , wherein the T cells are autologous to the patient.
3. The method of claim 1 , wherein the T cells are obtained from a healthy donor.
4. The method of claim 1 , wherein the T cells are obtained from tumor infiltrating lymphocytes or peripheral blood mononuclear cells.
5. The method of claim 1 , wherein the activated T cells are expanded in vitro.
6. The method of claim 1 , wherein the population of activated T cells are administered in the form of a composition.
7. The method of claim 6 , wherein the composition further comprises an adjuvant.
8. The method of claim 7 , wherein the adjuvant is selected from anti-CD40 antibody, imiquimod, resiquimod, GM-CSF, cyclophosphamide, sunitinib, bevacizumab, interferon-alpha, interferon-beta, CpG oligonucleotides and derivatives, poly-(I:C) and derivatives, RNA, sildenafil, particulate formulations with poly(lactide co-glycolide) (PLG), virosomes, interleukin (IL)-1, IL-2, IL-4, IL-7, IL-12, IL-13, IL-15, IL-21, and IL-23.
9. The method of claim 8 , wherein the adjuvant comprises IL-2.
10. The method of claim 8 , wherein the adjuvant comprises IL-21.
11. The method of claim 1 , wherein the cancer is lung cancer.
12. The method of claim 1 , wherein the cancer is GBM.
13. The method of claim 1 , wherein the cancer is GC.
14. The method of claim 1 , wherein the cancer is HCC.
15. The method of claim 1 , wherein the cancer is MEL.
16. The method of claim 1 , wherein the cancer is NHL.
17. The method of claim 1 , wherein the cancer is PRCA.
18. The method of claim 1 , wherein the cancer is RCC.
19. The method of claim 1 , wherein the cancer is UEC.
20. The method of claim 8 , wherein the adjuvant comprises IL-7.