Compositions comprising folic acid derivatives, their preparations and methods of use
Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.
1. A solid pharmaceutical composition comprising a compound of Formula (V):
wherein
R 1 and R 2 are each independently selected from H, OH, NH 2 , C 1-6 alkyl or aryl;
R 3 is H, C 1-6 alkyl or aryl; and
Y is halo.
2. The solid pharmaceutical composition of claim 1 , wherein R 1 is NH 2 .
3. The solid pharmaceutical composition of claim 1 , wherein R 2 is OH.
4. The solid pharmaceutical composition of claim 1 , wherein R 3 is H.
5. The solid pharmaceutical composition of claim 1 , wherein Y is chloro.
6. The solid pharmaceutical composition of claim 1 , wherein the solid pharmaceutical composition is a tablet.
7. The solid pharmaceutical composition of claim 1 , wherein the solid pharmaceutical composition is a dragee.
8. The solid pharmaceutical composition of claim 1 , wherein the solid pharmaceutical composition is a capsule.
9. The solid pharmaceutical composition of claim 1 , wherein the solid pharmaceutical composition is a pill.
10. The solid pharmaceutical composition of claim 1 , wherein the solid pharmaceutical composition is a granule.
11. The solid pharmaceutical composition of claim 1 , wherein the solid pharmaceutical composition is formulated for oral administration.