IP Library › Patent Application 16788083
Patent Application
App. No. 16/788,083

FREEZE-DRIED PRODUCT AND GAS-FILLED MICROVESICLES SUSPENSION

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
16/788,083
Abstract

Lipid formulation particularly for preparing stable gas-filled microvesicles, comprising distearoyl-phosphatidylcholine (DSPC), dipalmitoylphosphatidylethanolamine-PEG5000 (DPPE-PEG5000) and palmitic acid in an advantageous relative molar ratio. The formulation is useful in particular for therapeutic application with ultrasounds.

Claims (14)

1 . A freeze-dried formulation, for preparing gas-filled microvesicles, comprising a lipid mixture of DSPC, DPPE-PEG and palmitic acid in a respective molar amount of 65-85/4-10/8-22.

2 . The freeze-dried formulation of claim 1 wherein said respective molar amount is of 70-80/5-9/12-21.

3 . The freeze-dried formulation of claim 1 wherein said respective molar amount is of 72-76/6-8/15-20.

4 . The freeze-dried formulation of claim 1 wherein said respective molar amount is of 74 (+/−1)/7.5 (+/−0.5)/18.5(+/−1).

5 . The freeze-dried formulation of any of the preceding claims 1 to 4 further comprising a freeze-drying protective component.

6 . The freeze-dried formulation according to claim 5 , wherein freeze-drying protective component is PEG4000.

7 . The freeze-dried formulation according to claim 6 , wherein the weight of the lipid mixture is of from 0.08% to 0.3% with respect to the weight of PEG4000.

8 . The freeze-dried formulation according to claim 7 wherein said weight is of from 0.10% to 0.20%.

9 . The freeze-dried formulation according to claim 7 wherein said weight is of from 0.12% to 0.18% by weight

10 . The freeze-dried formulation according to claim 7 wherein said weight is of about 0.16%.

11 . A suspension of gas-filled microvesicles wherein said microvesicles comprise a mixture of DSPC, DPPE-PEG and palmitic acid in a respective molar amount of 65-85/4-10/8-22.

12 . The suspension of claim 11 wherein said respective molar amount is of 70-80/5-9/12-21.

13 . The suspension of claim 11 wherein said respective molar amount is of 72-76/6-8/15-20.

14 . The suspension of claim 11 wherein said respective molar amount is of 74 (+/−1)/7.5 (+/−0.5)/18.5(+/−1).