IP Library Granted Patent US 10,995,100
Granted Patent B2
US 10,995,100 · App. 16/795,394 · Granted May 4, 2021

Bicyclic heterocyclyl derivatives as IRAK4 inhibitors

Inventors: Venkateshwar Rao Gummadi (Bangalore, IN); Susanta Samajdar (Bangalore, IN)
Assignee: Aurigene Discovery Technologies Limited
C07D513/04C07D498/04C07D519/00
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Quick Facts
Patent No.
US 10,995,100
App. No.
16/795,394
Granted
May 4, 2021
Kind
B2
Abstract

The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X 1 , X 2 , X 3 , R 1 , R 3 , ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Claims (4)

1. A compound according to the following structure:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is

3. The compound of claim 1 , wherein the compound is a pharmaceutically acceptable salt of

Assignments (2)
CHANGE OF NAME Recorded Mar 3, 2025
From: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
To: AURIGENE ONCOLOGY LIMITED
Reel/Frame 070378/0823 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2020
From: GUMMADI, VENKATESHWAR RAO; SAMAJDAR, SUSANTA
To: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Reel/Frame 051979/0152 →
Priority Claims (2)
IN 158/CHE/2014 · Jan 13, 2014 · national
IN 3000/CHE/2014 · Jun 20, 2014 · national
Continuity (4)
Continuation 16054512 · Aug 3, 2018
Continuation 15667173 · Aug 2, 2017
Continuation 15111000
Related Publication 20200190112A1 · Jun 18, 2020
Cited By (1)
US 12,410,193