Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors
Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.
1. A crystalline form of Compound I:
wherein the crystalline form is sesqui-succinate Form III; and
wherein crystalline sesqui-succinate Form III is characterized by an X-ray powder diffractogram comprising characteristic peaks (±0.2° 2θ) at 7.8°±0.2° 2θ, 16.5°±0.2° 2θ, and 21.4°±0.2° 2θ.
2. The crystalline form according to claim 1 , wherein the crystalline form is further characterized by an X-ray powder diffractogram comprising additional characteristic peaks (±0.2° 2θ) at 12.2°±0.2° 2θ, 16.0°±0.2° 2θ, and 24.5°±0.2° 2θ.
3. The crystalline form according to claim 1 , wherein the crystalline form is further characterized by a differential scanning calorimetry thermogram comprising endothermic peaks having onset temperatures of 118° C., 136° C., and 186° C.
4. A pharmaceutical composition comprising the crystalline form according to claim 1 and a pharmaceutically acceptable excipient.