Methods and systems for J-coupled nuclear magnetic resonance

1. A nuclear magnetic resonance (NMR) system configured to detect combinatorial signatures stemming from homonuclear and heteronuclear J-couplings, the system comprising:

a pre-polarization system,

a detector,

a shuttling device configured to shuttle a sample between the pre-polarization system and the detector using a mechanical linear actuator or a flow-based or microfluidic-based device, wherein a shuttling time of the sample between the pre-polarization system and the detector is constant and configured to return the sample to the pre-polarization system for the sample to be re-analyzed by the detector, and wherein the constant shuttling time of the sample between the pre-polarization system and the detector creates a steady-state pre-polarization sample, and

NMR electronics,

wherein the detector includes an NMR magnet with a magnetic field of strength between 300 mT and 10 μT.

2. The system of claim 1 , wherein:

the detector further includes a shimming system configured to increase homogeneity of the magnetic field to values between 1-100 ppm.

3. The system of claim 1 , wherein the shuttling device is configured to shuttle the sample in a time interval less than 1 s.

4. The system of claim 1 , wherein the detector further includes an excitation coil and a detection coil.

5. The system of claim 4 , wherein the excitation coil and the detection coil are radio frequency coils.

6. The system of claim 1 , wherein the system is capable of detection for samples larger than 1 nL.

7. The system of claim 1 , wherein the system is capable of detection for samples containing different nuclei with concentrations between 110M and 1 μM.

8. The system of claim 1 , wherein the system is configured to detect one or more chemical war agents comprising organophosphorus compounds.

9. The system of claim 1 , wherein a size of the system is less than 1 cubic meter.

10. The system of claim 1 , wherein the system is portable.

11. The system of claim 1 , wherein a weight of the system is less than 20 Kg.

12. The system of claim 1 , wherein the system is configured to detect molecules with heteronuclear J-couplings of any form, including X M -A-B-X k , such that the heteronuclear J-coupling falls into one or more of the J-coupling regimes.

13. The system of claim 1 , wherein the system is configured to provide simultaneous excitation and detection (˜3 kHz) of all spin active nuclei in the sample using a uniformly exciting pulse.

14. The system of claim 1 , further comprising a resonant circuitry configured for detection.

15. The system of claim 1 , further comprising a non-resonant circuitry configured for detection.