IP Library Granted Patent US 11,696,713
Granted Patent B2
US 11,696,713 · App. 16/809,778 · Granted Jul 11, 2023

Contour electrocorticography (ECoG) array

Inventors: Junseok Chae (Scottsdale, AZ); Shiyi Liu (Asu, AZ); Alfredo Quinones-Hinojosa (Rochester, MN); Tito Vivas-Buitrago (Rochester, MN)
Assignees: Arizona Board of Regents on behalf of Arizona State University; Mayo Foundation for Medical Education and REsearch
A61B5/24A61B5/0031A61B5/6868A61B2562/046
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Quick Facts
Patent No.
US 11,696,713
App. No.
16/809,778
Granted
Jul 11, 2023
Kind
B2
Abstract

ElectroCorticoGraphy (ECoG) sensors and uses are disclosed. These ECoG arrays, systems, and processes may be operable or configured to: i) simultaneously record neural signals while providing stimulation on specific portions of the cortex using a user-guided stimulator; ii) acquire neural signals over a large cortex area; iii) provide individual or group stimulation while concurrently receiving neural feedback; and/or iv) acquire neural signals at a setting remote from the neural source using wireless or other communication techniques.

Claims (34)

1. A real-time neural electrocorticography (ECoG) measurement system comprising:

a flexible two-dimensional substrate, the substrate comprising a plurality of tines with each tine comprising a plurality of sensors,

wherein each tine has an arc of curvature, the arc of curvature being at least nineteen centimeters in length,

wherein the substrate comprises a biocompatible material,

wherein a plurality of open spacings exist between adjacent tines of the plurality of tines;

a wired connector connected to an output of the plurality of sensors; and

a wireless transceiver in communication with the wired connector,

wherein each sensor of the plurality of sensors has a mass of 3.0 mg to 98 mg, and

wherein the transceiver has circuit topology configured to send neural signals received from the sensors to a system monitor.

2. The system of claim 1 wherein circuit topology of the transceiver is configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between sensors of the plurality of sensors.

3. The system of claim 1 wherein the system monitor is configured to receive the contemporaneous neural signals from the transceiver and to record the received contemporaneous neural signals.

4. The system of claim 1 further comprising a coating of medical grade silicone with a thickness of no more than 0.8 mm.

5. The system of claim 1 wherein the substrate comprises no more than 0.8 mm of medical grade silicone.

6. The system of claim 1 wherein the flexible two-dimensional substrate is in the shape of a trident.

7. The system of claim 1 wherein the sensors are equidistantly spaced along tines of the substrate.

8. The system of claim 1 wherein the plurality of open spacings further comprises end recesses between the adjacent tines of the plurality of tines.

9. The system of claim 1 wherein at least one cross-member connects the adjacent tines of the plurality of tines.

10. A real-time neural electrocorticography (ECoG) measurement system comprising:

a flexible two-dimensional substrate, the substrate comprising a plurality of arrays with each array comprising a plurality of electrodes,

wherein each array has a radius of curvature, the radius of curvature being at least nineteen centimeters in length,

wherein the substrate comprises a biocompatible material,

wherein a plurality of open spacings exist between adjacent arrays of the plurality of arrays;

a wired connector connected to an output of the plurality of electrodes; and

a wireless transceiver in communication with the wired connector,

wherein each electrode of the plurality of electrodes has a mass of 3.0 mg to 98 mg, and

wherein the transceiver has circuit topology configured to send neural signals received from the electrodes to a system monitor.

11. The system of claim 10 wherein the arrays are one-dimensional arrays.

12. The system of claim 10 wherein circuit topology of the transceiver is configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between electrodes of the plurality of electrodes.

13. The system of claim 10 wherein the system monitor is configured to receive the contemporaneous neural signals from the transceiver and to record the received contemporaneous neural signals.

14. The system of claim 10 wherein the substrate comprises no more than 0.8 mm of medical grade silicone.

15. The system of claim 10 wherein the flexible two-dimensional substrate is in the shape of a polygon.

16. The system of claim 10 wherein the sensors are equidistantly spaced along one-dimensional arrays of the substrate.

17. The system of claim 10 wherein the plurality of open spacings further comprises end recesses between the adjacent arrays of the plurality of arrays.

18. The system of claim 10 wherein at least one cross-member connects the adjacent arrays of the plurality of arrays.

Assignments (4)
CONFIRMATORY LICENSE Recorded May 10, 2023
From: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 063601/0103 →
CONFIRMATORY LICENSE Recorded Dec 1, 2020
From: ARIZONA STATE UNIVERSITY, TEMPE
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 054555/0133 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 5, 2020
From: QUINONES-HINOJOSA, ALFREDO; VIVAS-BUITRAGO, TITO
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 052024/0379 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 5, 2020
From: CHAE, JUNSEOK; LIU, SHIYI
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 052095/0819 →
Continuity (2)
Provisional Application 62819042 · Mar 15, 2019
Related Publication 20200289002A1 · Sep 17, 2020