Methods and compositions comprising ursolic acid and/or resveratrol for treating diabetes, or cancer
Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
1. A method of increasing cellular glucose uptake in a human, the method comprising:
administering an effective amount of a nutritional supplement to increase cellular glucose uptake in the human,
wherein the effective amount of the nutritional supplement comprises a ratio of ursolic acid to resveratrol of about 3:1 to 1:3,
wherein the nutritional supplement is formulated for oral consumption as a tablet, a capsule, a concentrate, a powder, a drink, or a food,
wherein the nutritional supplement is in addition to food in a normal diet, and
wherein the nutritional supplement is formulated to be consumed one or more times per day;
continuing the administering for multiple days; and
increasing the cellular glucose uptake in the human.
2. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 50 to 600 mg of ursolic acid.
3. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 200 mg of ursolic acid.
4. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 50 to 600 mg resveratrol.
5. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 600 mg of resveratrol.
6. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 200 mg of ursolic acid and 600 mg of resveratrol.
7. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 100 mg of ursolic acid and 200 mg of resveratrol.
8. The method of claim 1 , wherein the nutritional supplement comprises one or more of a preserving, an emulsifying, or a dispersing agent.
9. The method of claim 1 , wherein the nutritional supplement comprises one or more of a filler or extender, a binder, a humectant, a disintegrating agent, solution retarder, absorption accelerator, wetting agent, an adsorbent, lubricant, or buffering agent.
10. The method of claim 9 , wherein the filler is starch, lactose, sucrose, mannitol, or silicic acid.
11. The method of claim 9 , wherein the binder is carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose, or acacia.
12. The method of claim 9 , wherein the humectant is glycerol.
13. The method of claim 9 , wherein the disintegrating agent is agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, complex silicates, or sodium carbonate.
14. The method of claim 9 , wherein the solution retarder is paraffin.
15. The method of claim 9 wherein the wetting agent is cetyl alcohol or glycerol monostearate.
16. The method of claim 9 , wherein the lubricant is talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, or mixtures thereof.
17. The method of claim 1 , wherein the food comprises a baked good, chocolate, caramel, cookie, or bar.