Orthodontic adhesives and methods of using same
An orthodontic adhesive includes components capable of allowing easy debonding of an orthodontic device from a patient's tooth. The adhesive includes an engineered marine mussel protein. The adhesive may include at least one photocleavable moiety. The adhesive is applied in one or more individual layers. One of the components of the adhesive is capable of binding to a tooth and the other component may be capable of binding to an orthodontic device. A method of adhering an orthodontic device to a tooth includes applying a layer of an orthodontic adhesive to either the tooth or the orthodontic device or the tooth and the orthodontic device and affixing the orthodontic device to the tooth with the orthodontic adhesive situated between the tooth and the orthodontic device. The engineered marine mussel protein includes one or more catechol moieties or one or more derivatives of a catechol moiety.
1. A dental article for use in the mouth comprising:
an orthodontic appliance having a base for bonding the appliance to a tooth; and
an adhesive system on the base of the orthodontic appliance, the adhesive system comprising:
an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety, and
a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine,
wherein the adhesive system exhibits a shear bond strength from 10 MPa to 20 MPa after bonded to the tooth.
2. The article of claim 1 wherein the adhesive system is photo-curable.
3. The article of claim 1 wherein the engineered marine mussel protein includes catechol-methacrylate.
4. The article of claim 1 wherein the catechol moiety is a photocleavable bis-methacrylate.
5. The article of claim 1 wherein the adhesive system further comprises a resin, the resin selected from the group consisting of acrylate resins and methacrylate resins.
6. A dental article for use in the mouth comprising:
an orthodontic appliance having a base for bonding the appliance to a tooth; and
an adhesive system on the base of the orthodontic appliance the adhesive system comprising:
a first portion including a monomer of an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety; and
a second portion on the base of the appliance between the base of the appliance and the monomer, the second portion comprising a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine, and a photoinitiator, and
wherein the adhesive system exhibits a shear bond strength from 10 MPa to 20 MPa after bonded to the tooth.
7. The article of claim 6 wherein the second portion further comprises a sealant.
8. A kit comprising:
an orthodontic device; and
an adhesive system comprising a first component including an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety, and a separate, second component including a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine,
wherein the second component is configured to be applied to the first component to form the adhesive system, the adhesive system is configured to be applied to the orthodontic device and a tooth to form a bond binding the orthodontic device to the tooth, and the bond exhibiting a shear bond strength from 10 MPa to 20 MPa.
9. The kit of claim 8 wherein the second component further comprises a sealant.
10. The kit of claim 8 wherein the adhesive system is precoated on a base of the orthodontic device.
11. The kit of claim 8 further comprising a third component including a sealant.
12. The kit of claim 11 further comprising a fourth component including a photo-initiator.
13. The kit of claim 8 further comprising a third component including a photo-initiator.
14. A method of bonding an orthodontic appliance to a tooth comprising:
providing an orthodontic appliance having a base for bonding the orthodontic appliance to a tooth and an adhesive system on the base, the adhesive system comprising:
an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety,
a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine, and
a sealant;
applying the adhesive system on the base to the tooth; and
curing the adhesive system with light.
15. A method of bonding an orthodontic appliance to a tooth comprising:
applying a layer of an adhesive system to the orthodontic appliance, the adhesive system comprising:
an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety, and
a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine; and
applying the base of the appliance to the tooth by way of applying the adhesive system on the base to the tooth; and
curing the adhesive system with light.
16. The method of claim 15 , wherein the adhesive system exhibits a shear bond strength from 10 MPa to 20 MPa after bonded to the tooth.
17. The method of claim 15 , wherein applying the base of the appliance to the tooth is performed without cleaning, etching, or drying the tooth.
18. The method of claim 15 , wherein in the applying the layer of the adhesive system step, a surface of the tooth is not treated with any compositions before the applying the layer of the adhesive system step.
19. An orthodontic adhesive system comprising:
an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety, and
a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine, and
wherein the adhesive system exhibits a shear bond strength from 10 MPa to 20 MPa after bonded to a tooth.
20. An orthodontic adhesive system comprising:
an engineered marine mussel protein including at least one catechol moiety or catechol derivative moiety, and
a nitrocatechol derivative selected from the group consisting of nitrodopamine, nitronorepinephrine, and nitroepinephrine, and a photo-initiator.
21. The orthodontic adhesive system according to claim 20 wherein the photo-initiator is photo-curable.
22. The orthodontic adhesive system according to claim 20 wherein the engineered marine mussel protein includes catechol-methacrylate.
23. The orthodontic adhesive system according to claim 20 wherein the catechol moiety is a photocleavable bis-methacrylate.
24. The orthodontic adhesive system according to claim 20 further comprising a resin selected from the group consisting of acrylate resins and methacrylate resins.