Methods of treating hypertriglyceridemia
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
1. A method of reducing vLDL particle size in a subject having a fasting baseline triglyceride level of about 500 mg/dl to about 1500 mg/dl comprising administering to the subject about 4 g per day ethyl eicosapentaenoate thereby to produce a reduction in vLDL particle size.
2. The method of claim 1 wherein said reduction is statistically significant.
3. The method of claim 1 wherein administering to the subject about 4 g per day of ethyl eicosapentaenoate produces a reduction in vLDL particle size by comparison with a baseline vLDL particle size prior to initiation of administration.
4. The method of claim 3 wherein the reduction in vLDL particle size is at least a 2.5% reduction.
5. The method of claim 3 wherein the reduction in vLDL particle size is at least a 5% reduction.
6. The method of claim 3 wherein the reduction in vLDL particle size is at least a 8% reduction.
7. The method of claim 1 wherein the subject is administered about 3.8 g to about 4 g per day of ethyl eicosapentaenoate.
8. The method of claim 1 wherein the subject is administered ethyl eicosapentaenoate for a period of 12 weeks.
9. The method of claim 1 , wherein the ethyl eicosapentaenoate is administered to the subject 1 to 4 times per day.
10. The method of claim 1 , wherein the ethyl eicosapentaenoate is present in one or more capsules.