Melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promotor and wrinkle ameliorant
The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]
1. A composition comprising, as an active ingredient thereof, an orotic acid derivative represented by the following general formula (1) or a salt thereof and containing 1% by weight to 99.9% by weight of water:
wherein, R represents a side chain of a hydrophilic naturally-occurring amino acid selected from the group consisting of serine, threonine, cysteine, asparagine, glutamine, and histidine.
2. The composition according to claim 1 , further comprising carriers or additives pharmaceutically or cosmetically acceptable for use as external skin preparations or cosmetics.
3. The composition according to claim 1 , wherein the concentration of the orotic acid derivative or salt thereof is 1.0×10 −6 % (w/v) to 10% (w/v).
4. The composition according to claim 1 , wherein a pH of the composition is 2 to 8.
5. The composition according to claim 1 , wherein R in the formula (1) represents a side chain of histidine.
6. The composition according to claim 5 , further comprising carriers or additives pharmaceutically or cosmetically acceptable for use as external skin preparations or cosmetics.
7. The composition according to claim 5 , wherein the concentration of the orotic acid derivative or salt thereof is 1.0×10 −6 % (w/v) to 10% (w/v).
8. The composition according to claim 5 , wherein a pH of the composition is 2 to 8.
9. A composition comprising, as an active ingredient thereof, an orotic acid derivative represented by the following general formula (1) or a salt thereof:
wherein, R represents a side chain of a hydrophilic naturally-occurring amino acid selected from the group consisting of serine, threonine, cysteine, asparagine, glutamine, and histidine; and
the concentration of the orotic acid derivative or salt thereof is 1.0×10 −6 % (w/v) to 10% (w/v).
10. The composition according to claim 9 , further comprising carriers or additives pharmaceutically or cosmetically acceptable for use as external skin preparations or cosmetics.
11. The composition according to claim 9 , wherein a pH of the composition is 2 to 8.
12. The composition according to claim 9 , wherein R in the formula (1) represents a side chain of histidine.