Systems and methods of tissue closure
Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.
1. A system for closing a tissue structure, wherein the system includes a closure device in combination with a closure device applicator, wherein the closure device comprises
a compression body provided with at least two compliant opposing tissue-engaging surfaces capable of engaging opposite sides of a tissue structure, the compression body including a scaffold; and
wherein the closure device applicator comprises
a jaw mechanism that includes two jaws, wherein each jaw is adapted to detachably engage the compression body so as to arrange the two compliant opposing tissue-engaging surfaces to engage opposite sides of the tissue structure.
2. The system as in claim 1 , wherein the tissue structure is a left atrial appendage.
3. The system as in claim 1 , wherein the tissue-engaging surfaces of the compression body are comprised of a soft, biologically compatible polymer.
4. The system as in claim 3 , wherein the tissue-engaging surfaces possess a three-dimensional compliance that permits the soft tissue-engaging surfaces to conform to a three-dimensional topography of the tissue structure when the jaw mechanism compresses the compression body on the tissue structure.
5. The system as in claim 1 , wherein the compression body has a port formed therein for each jaw of the closure device applicator so that the compression body is detachably engageable with the closure device applicator via these ports.
6. The system as in claim 1 , wherein the two jaws of the closure device applicator are operably connected to one another so as to be spreadable when a trigger is activated.
7. The system as in claim 1 , wherein the at least two compliant opposing tissue-engaging surfaces each form a portion of a single continuous surface.
8. The system as in claim 7 , wherein the at least two compliant opposing tissue-engaging surfaces are connected via a third compliant surface.
9. The system as in claim 8 , wherein the at least two compliant opposing tissue-engaging surfaces are parallel surfaces.
10. The system as in claim 1 , wherein the at least two compliant opposing tissue-engaging surfaces are non-parallel surfaces.
11. The system as in claim 10 , wherein the at least two compliant opposing tissue-engaging surfaces are curved surfaces.
12. The system as in claim 11 , wherein the at least two compliant opposing tissue-engaging surfaces are concave surfaces.
13. A closure device configured to close a tissue structure, wherein the closure device comprises:
a compression body provided with at least two compliant opposing tissue-engaging surfaces capable of engaging opposite sides of a tissue structure, wherein the compression body includes a scaffold.
14. The closure device as in claim 13 , wherein the tissue structure is a left atrial appendage.
15. The closure device as in claim 13 , wherein the tissue-engaging surfaces of the compression body are comprised of a soft, biologically compatible polymer.
16. The closure device as in claim 13 , wherein the tissue-engaging surfaces possess a three-dimensional compliance that permits the soft tissue-engaging surfaces to conform to a three-dimensional topography of the tissue structure when a jaw mechanism compresses the compression body on the tissue structure.
17. The closure device as in claim 13 , wherein the at least two compliant opposing tissue-engaging surfaces each form a portion of a single continuous surface.
18. The closure device as in claim 17 , wherein the at least two compliant opposing tissue-engaging surfaces are connected via a third compliant surface.
19. The closure device as in claim 13 , wherein the at least two compliant opposing tissue-engaging surfaces are non-parallel surfaces.
20. The closure device as in claim 19 , wherein the at least two compliant opposing tissue-engaging surfaces are curved surfaces.