Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application
The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.
1. A compound having Formula II-B:
or a pharmaceutically acceptable salt thereof, wherein:
R 2 is CD 3 ;
X is 18 F or F;
Y is —[O(CR a R b ) 2 ] m —, wherein R a and R b are each independently hydrogen or deuterium atoms;
m is 3; and
A 1 is N or CH.
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Y is —[O(CR s R b ) 2 ] 3 —.
3. The compound of claim 1 , having Formula II-C:
or a pharmaceutically acceptable salt thereof, wherein:
A 1 is N or CH; and
X is 18 F or F.
4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof,
wherein A 1 is N and X is 18 F.
5. The compound of claim 2 , or a pharmaceutically acceptable salt thereof,
wherein A 1 is N and X is 18 F.
6. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
7. A method of in vivo imaging, comprising
administering an effective amount of the compound of claim 1 wherein X is 18 F, or a pharmaceutically acceptable salt thereof to a subject; and
scanning said subject to detect the pattern of positron emission tomography, whereby an image is generated from the pattern of positron emission.
8. A pharmaceutical composition comprising the compound of claim 4 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
9. A method of in vivo imaging, comprising
administering an effective amount of the compound of claim 4 or a pharmaceutically acceptable salt thereof to a subject; and
scanning said subject to detect the pattern of positron emission tomography, whereby an image is generated from the pattern of positron emission.
10. A pharmaceutical composition comprising the compound of claim 5 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
11. A method of in vivo imaging, comprising
administering an effective amount of the compound of claim 5 or a pharmaceutically acceptable salt thereof to a subject; and
scanning said subject to detect the pattern of positron emission tomography, whereby an image is generated from the pattern of positron emission.
12. The compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein A 1 is N and X is F.
13. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein A 1 is N and X is F.