Solid forms of cannabidiol and uses thereof
Disclosed herein are cocrystals of cannabidiol and a coformer containing 5-6 membered rings comprised of carbon and nitrogen atoms, wherein the 5-6 membered rings can be unsaturated or saturated and the rings contain 1 to 2 nitrogen atoms. Cocrystals of cannabidiol and a coformer selected from L-proline, D-proline, tetramethylpyrazine, and 4,4′-dipyridyl are also disclosed herein.
1. A method for treating a disease or condition in a subject having said disease or condition, comprising administering to said subject a pharmaceutical composition comprising a solid form of cannabidiol and the coformer tetramethylpyrazine, wherein the solid form has an x-ray diffraction pattern comprising one or more peaks at about 9.1, 14.6, 18.3, and 19.6 degrees 2θ±0 as obtained using Cu Kα radiation.
2. The method of claim 1 , wherein the disease or condition is selected from one or more of central nervous system disorders, cardiovascular disorders, neurovascular disorders, neuromuscular disorders, cancers, autoimmune disorders, inflammation, pain, sleep disorders, posttraumatic stress disorder, posttraumatic stress syndrome; nausea, and hypoxia-ischemia.
3. The method of claim 1 , wherein the disease or condition is selected from one or more of a solid tumor, cancer metastasis, multiple sclerosis, multiple sclerosis-related muscle spasms, Parkinson's disease, psychosis; epilepsy, treatment-resistant epilepsy, epilepsy in tuberous sclerosis complex, Dravet syndrome, febrile infection-related epilepsy syndrome (Fires) in the acute and chronic phases, Sturge-Weber Syndrome, status epilepticus, malignant migrating partial seizures, brain tumor-related epilepsy, seizures caused by early onset epilepsy, Lennox-Gastaut Syndrome, psychiatric disorders, impaired cognitive function, cognitive impairment in schizophrenia, anxiety, depression, bipolar disorders, fibromyalgia, hepatitis, epidermolysis bullosa, spasticity in neurodegenerative diseases, cachexia, anorexia, ocular hypertension in glaucoma, movement disorders, dystonic disorders, Prader Willi syndrome, spasms in Tourette syndrome, pseudobulbar affect, reducing drug dependence, addiction, smoking addiction, opioid addiction, diabetes mellitus, graph versus host disease (GVHD), atherosclerosis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, cutaneous lupus erythematosus, psoriasis, autoimmune uveitis, autoimmune hepatitis, hypersensitivity lung diseases, hypersensitivity pneumonitis, delayed-type hypersensitivity, Sjogren's disease, thyroid disease, acquired immunodeficiency syndrome, sarcoidosis, rheumatoid arthritis, interstitial lung disease, scleroderma, dermatitis; iritis, conjunctivitis, keratoconjunctivitis, idiopathic bilateral progressive sensorineural hearing loss, aplastic anemia, pure red cell anemia, idiopathic thrombocytopenia, polychondritis, Graves ophthalmopathy, amyotrophic lateral sclerosis (ALS) and symptoms associated with ALS, primary biliary cirrhosis, ileitis, chronic inflammatory intestinal disease, celiac disease, irritable bowel syndrome, Alzheimer's disease, prion associated disease, fatty liver; insomnia (onset and maintenance), sleep disorders in Parkinson's, acne, cannabis withdrawal symptoms, OCD, nausea, nausea related to cancer treatment, vomiting, emesis, motion sickness, and acute stroke.
4. The method according to claim 2 , wherein the cancer is selected from one or more of anaplastic ependymoma, DIPG, Glioblastoma multiforme, bladder, breast, head and neck, prostate, neuroendocrine, Non-Hodgkin's lymphoma, non-small cell lung, colorectal, pancreatic, and ovarian.
5. The method of claim 1 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable excipient or carrier.
6. The method of claim 1 , wherein the solid form further comprises a molar ratio of cannabidiol to tetramethylpyrazine of about 1:1.
7. The method of claim 1 , wherein the solid form further comprises a crystalline form.
8. The method of claim 1 , wherein the solid form further comprises a cocrystal.
9. The method of claim 1 , wherein the solid form further comprises a DSC thermogram with a peak onset of approximately 89.9° C. or a peak maximum at about 92.8° C.
10. A method for treating a disease or condition in a subject in need of treatment having said disease or condition, comprising administering to said subject a pharmaceutical composition comprising a cocrystal of cannabidiol and the coformer tetramethylpyrazine in a molar ratio of about 1:1, wherein the cocrystal has an x-ray diffraction pattern comprising one or more peaks at about 9.1, 14.6, 18.3, and 19.6 degrees 2θ±0.2 as obtained using Cu Kα radiation.
11. The method of claim 10 , wherein the disease or condition is selected from one or more of central nervous system disorders, cardiovascular disorders, neurovascular disorders, neuromuscular disorders, cancers, autoimmune disorders, inflammation, pain, sleep disorders, posttraumatic stress disorder, posttraumatic stress syndrome, nausea, and hypoxia-ischemia.
12. The method of claim 10 , wherein the disease or condition is selected from one or more of a solid tumor, cancer metastasis, multiple sclerosis, multiple sclerosis-related muscle spasms, Parkinson's disease, psychosis; epilepsy, treatment-resistant epilepsy, epilepsy in tuberous sclerosis complex, Dravet syndrome, febrile infection-related epilepsy syndrome (Fires) in the acute and chronic phases, Sturge-Weber Syndrome, status epilepticus, malignant migrating partial seizures, brain tumor-related epilepsy, seizures caused by early onset epilepsy, Lennox-Gastaut Syndrome, psychiatric disorders, impaired cognitive function, cognitive impairment in schizophrenia, anxiety, depression, bipolar disorders, fibromyalgia, hepatitis, epidermolysis bullosa, spasticity in neurodegenerative diseases, cachexia, anorexia, ocular hypertension in glaucoma, movement disorders, dystonic disorders, Prader Willi syndrome, spasms in Tourette syndrome, pseudobulbar affect, reducing drug dependence, addiction, smoking addiction, opioid addiction, diabetes mellitus, graph versus host disease (GVHD), atherosclerosis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, cutaneous lupus erythematosus, psoriasis, autoimmune uveitis, autoimmune hepatitis, hypersensitivity lung diseases, hypersensitivity pneumonitis, delayed-type hypersensitivity, Sjogren's disease, thyroid disease, acquired immunodeficiency syndrome, sarcoidosis, rheumatoid arthritis, interstitial lung disease, scleroderma, dermatitis, iritis, conjunctivitis, keratoconjunctivitis, idiopathic bilateral progressive sensorineural hearing loss, aplastic anemia, pure red cell anemia, idiopathic thrombocytopenia, polychondritis, Graves ophthalmopathy, amyotrophic lateral sclerosis (ALS) and symptoms associated with ALS, primary biliary cirrhosis, ileitis, chronic inflammatory intestinal disease, celiac disease, irritable bowel syndrome, Alzheimer's disease, prion associated disease, fatty liver, insomnia (onset and maintenance), sleep disorders in Parkinson's, acne, cannabis withdrawal symptoms; OCD, nausea, nausea related to cancer treatment, vomiting, emesis, motion sickness, and acute stroke.
13. The method according to claim 11 , wherein the cancer is selected from one or more of anaplastic ependymoma, DIPG, Glioblastoma multiforme, bladder, breast, head and neck, prostate, neuroendocrine, Non-Hodgkin's lymphoma, non-small cell lung, colorectal, pancreatic, and ovarian.
14. The method of claim 10 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable excipient or carrier.