Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
1. A method of improving the efficacy of bupropion in treating depression, comprising: orally administering about 90 mg to about 125 mg of a bupropion in combination with about 40 mg to about 70 mg of a dextromethorphan, once a day or twice a day for at least 14 days, to a human being suffering from depression, wherein orally administering the bupropion in combination with the dextromethorphan is more effective in treating depression than orally administering the same dosage regimen of the bupropion without the dextromethorphan.
2. The method of claim 1 , wherein about 40 mg to about 50 mg of the dextromethorphan is orally administered once a day or twice a day.
3. The method of claim 1 , wherein about 45 mg of the dextromethorphan is orally administered once a day or twice a day.
4. The method of claim 1 , wherein about 100 mg to about 120 mg of the bupropion is orally administered once a day or twice a day.
5. The method of claim 2 , wherein about 105 mg of the bupropion is orally administered once a day or twice a day.
6. The method of claim 1 , wherein the dextromethorphan and the bupropion are orally administered for at least 35 days.
7. The method of claim 1 , wherein the human being is suffering from treatment-resistant depression.
8. The method of claim 1 , wherein the dextromethorphan is orally administered in a dosage form that provides immediate release of the dextromethorphan.
9. The method of claim 3 , wherein the dextromethorphan is orally administered in a dosage form that provides immediate release of the dextromethorphan.
10. The method of claim 1 , wherein the bupropion is orally administered in a dosage form that provides sustained release of the bupropion.
11. The method of claim 5 , wherein the bupropion is orally administered in a dosage form that provides sustained release of the bupropion.
12. The method of claim 10 , wherein about 105 mg of the bupropion is orally administered once a day or twice a day in a dosage form that provides sustained release of the bupropion.
13. The method of claim 12 , wherein the bupropion and the dextromethorphan are orally administered together in a single dosage form that is orally administered once a day or twice a day.
14. The method of claim 13 , wherein the dextromethorphan and the bupropion are orally administered for at least 5 weeks.
15. The method of claim 1 , wherein the human being is suffering from major depressive disorder.
16. The method of claim 14 , wherein the bupropion comprises an enantiomeric excess of an R-enantiomer.
17. The method of claim 14 , wherein the bupropion comprises an enantiomeric excess of an S-enantiomer.
18. The method of claim 1 , wherein the dextromethorphan comprises a deuterium-modified dextromethorphan.
19. A method of treating treatment-resistant depression comprising:
orally administering a dextromethorphan-bupropion combination once a day or twice a day for at least about two weeks to a human being suffering from depression, wherein the human being is selected for having treatment-resistant depression; and
wherein the dextromethorphan-bupropion combination comprises about 40 mg to about 70 mg of a dextromethorphan and about 100 mg to about 140 mg of a bupropion.
20. The method of claim 19 , wherein the bupropion comprises an enantiomeric excess of an enantiomer.
21. The method of claim 19 , wherein the dextromethorphan comprises a deuterium-modified dextromethorphan.
22. The method of claim 19 , wherein the dextromethorphan-bupropion combination comprises about 40 mg to about 50 mg of the dextromethorphan.
23. The method of claim 19 , wherein the dextromethorphan-bupropion combination comprises about 100 mg to about 110 mg of the bupropion.
24. The method of claim 22 , wherein the dextromethorphan-bupropion combination comprises about 100 mg to about 110 mg of the bupropion.
25. The method of claim 24 , wherein the dextromethorphan and the bupropion are orally administered in a single dosage form that provides immediate release for the dextromethorphan and sustained release for the bupropion.
26. The method of claim 25 , further comprising orally administering the dextromethorphan-bupropion combination once a day prior to orally administering the dextromethorphan-bupropion combination twice a day to the human being for at least about five weeks in total.
27. The method of claim 26 , wherein the dextromethorphan-bupropion combination comprises about 45 mg of the dextromethorphan.
28. The method of claim 27 , wherein the dextromethorphan-bupropion combination comprises about 105 mg of the bupropion.