IP Library › Granted Patent US 12,005,128
Granted Patent B1
US 12,005,128 · App. 16/838,907 · Granted Jun 11, 2024

Near infrared small molecule probes for the detection of cellular senescence

Inventors: Lina Cui (Gainesville, FL); Jun Liu (Gainesville, FL); Xiaowei Ma (Gainesville, FL); Ying Wang (Albuquerque, NM); Philip Deenik (Albuquerque, NM)
Assignee: UNM Rainforest Innovations
A61K49/0043A61K49/0058G01N33/582C07D491/052G01N2458/00
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Quick Facts
Patent No.
US 12,005,128
App. No.
16/838,907
Granted
Jun 11, 2024
Kind
B1
Abstract

A probe comprising a biomarker-triggered moiety, a near infrared (NIR) fluorophore reporter, a self-immolative linker and a self-immobilizing moiety for visualization of senescent cells and methods of use thereof.

Claims (5)

1. A probe for visualization of senescent cells wherein the probe has the chemical structure:

where R is CHF 2 .

2. A method for detecting or visualizing cell senescence comprising delivering to one or more cells a senescence visualizing probe having the chemical structure:

where R is CHF 2 .

3. The method of claim 2 wherein the cells are in vivo.

Assignments (1)
CONFIRMATORY LICENSE Recorded Oct 2, 2023
From: UNIVERSITY OF NEW MEXICO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065091/0302 →
Continuity (1)
Provisional Application 62828242 · Apr 2, 2019