Granted Patent B2

US 12,636,185 · App. 16/840,300 · Granted May 26, 2026

Inventors: Marc D. Friedman (Needham, MA); Desmond Adler (Bedford, MA)

Assignee: Avedro, Inc.

A61F9/0026A61F9/008A61F9/04A61M13/00A61N5/062A61F2009/00872A61M2202/0208A61N2005/0648A61N2005/0661A61N5/067

Abstract

Claims (39)

1 . A system for treating a first and second cornea of a first and second eye, comprising:

a mask device configured to be positioned over the first and second eyes of a face, the mask device including an anterior side and a posterior side, the posterior side configured to be positioned proximate to the face and rest against the face when a patient is lying on his/her back and the anterior side configured to be positioned distally from the face, the mask device including an outer wall extending at least between the anterior side and the posterior side, the outer wall defining a chamber extending across the first and second eyes, the chamber including a first section and a second section, the first section configured to be positioned over the first eye, the second section configured to be positioned over the second eye, the anterior side including a first transmission region forming a first aperture over the first section and a second transmission region forming a second aperture over the second section, the first transmission region allowing a first photoactivating light for the first eye to be delivered directly into the first cornea, the second transmission region allowing a second photoactivating light for the second eye to be delivered directly into the second cornea, the mask device including at least one diffuser;

at least one gas source storing a gas that is different than ambient air;

a gas delivery system coupling the at least one gas source to the mask device, the gas delivery system configured to deliver the stored gas into the chamber of the mask device;

a first solution applicator configured to deliver a first solution directly into the first cornea, and a second solution applicator configured to deliver a second solution directly into the second cornea; and

a processor coupled to the mask device and configured to determine parameters relating to the gas delivered into the chamber of the mask device,

wherein the at least one diffuser is configured to direct gas through an opening of the posterior side of the mask device, and

wherein the mask is configured for the gas to pass from the chamber through at least one of the first aperture and the second aperture.

2 . The system of claim 1 , wherein the gas includes an increased concentration of oxygen greater than an ambient concentration of oxygen in the ambient air.

3 . The system according claim 2 , wherein the parameters relate to oxygenation conditions for achieving cross-linking activity in at least one of the first or second eyes.

4 . The system of claim 1 , wherein the at least one gas source includes a gas source coupled to the mask device via a tube.

5 . The system of claim 1 , further comprising at least one illumination device configured to deliver at least one of the first photoactivating light or the second photoactivating light.

6 . The system of claim 1 , wherein the first photoactivating light and the second photoactivating light are delivered according to different treatment parameters.

7 . The system of claim 1 , wherein the first transmission region includes a first window formed in the anterior side and the second transmission region is a second window formed in the anterior side.

8 . The system of claim 1 , wherein the mask device is configured to keep the gas from the at least one gas source at a predetermined pressure.

9 . The system of claim 1 , wherein the gas can flow across the chamber, from the first section to the second section and vice versa.

10 . The system of claim 1 , wherein the mask device includes an inner wall separating the first section and the second section in the chamber of the mask device.

11 . A method for treating a first and second cornea of a first and second eye via a mask device positioned over first and second eyes of a face, the mask device including an anterior side and a posterior side, the posterior side configured to be positioned proximate to the face and rest against the face when a patient is lying on his/her back and the anterior side configured to be positioned distally from the face, the mask device including an outer wall extending at least between the anterior side and the posterior side, the outer wall defining a chamber extending across the first and second eyes, the chamber including a first section and a second section, the first section configured to be positioned over the first eye, the second section configured to be positioned over the second eye, the anterior side including a first transmission region forming a first aperture over the first section and a second transmission region forming a second aperture over the second section, the mask device including at least one diffuser, the diffuser configured to direct gas through an opening of the posterior side of the mask device, wherein the mask is configured for the gas to pass from the chamber through at least one of the first aperture and the second aperture, the method comprising:

at least one of transmitting a first photoactivating light to the first eye via the first transmission region directly to the first cornea, or transmitting a second photoactivating light to the second eye via the second transmission region directly to the second cornea;

delivering a gas different than ambient air from at least one gas source into the chamber of the mask device, the at least one gas source being coupled to the mask device via a gas delivery system;

applying a first solution via an applicator configured to deliver a first solution directly into the first cornea;

applying a second solution via the applicator configured to deliver the second solution directly into the second cornea; and

determining parameters relating to the gas delivered into the chamber of the mask device for delivering.

12 . The method of claim 11 , wherein the gas includes an increased concentration of oxygen greater than an ambient concentration of oxygen in the ambient air.

13 . The method of claim 12 , wherein the parameters relate to oxygenation conditions for achieving cross-linking activity in at least one of the first or second eyes with the first photoactivating light or the second photoactivating light.

14 . The method of claim 11 , further comprising controlling the gas delivered into the chamber of the mask device according to the oxygenation conditions for achieving the cross-linking activity.

15 . The method of claim 11 , wherein the first photoactivating light and the second photoactivating light are delivered according to substantially different illumination parameters.

16 . The method of claim 11 , wherein:

the first photoactivating light is delivered to the first eye by a first illumination device; and

the second photoactivating light is delivered to the second eye by a second illumination device.

17 . The method of claim 11 , further comprising keeping the gas from the at least one gas source at a predetermined pressure in the mask device.

18 . A system for treating a first and second cornea of a first and second eye, comprising:

a mask device configured to be positioned over the first and second eyes of a face, the mask device including an anterior side and a posterior side, the posterior side configured to be positioned proximate to the face and rest against the face when a patient is lying on his/her back and the anterior side configured to be positioned distally from the face, the mask device including an outer wall extending at least between the anterior side and the posterior side, the outer wall defining a chamber extending across the first and second eyes, the chamber including a first section and a second section, the first section configured to be positioned over the first eye, the second section configured to be positioned over the second eye, the anterior side including a first transmission region forming a first aperture over the first section and a second transmission region forming a second aperture over the second section, the first transmission region allowing a first photoactivating light for the first eye to be delivered directly into the first cornea, the second transmission region allowing a second photoactivating light for the second eye to be delivered directly into the second cornea, the mask device including at least one diffuser;

at least one gas source storing a gas that is different than ambient air;

a gas delivery system coupling the at least one gas source to the mask device, the gas delivery system configured to deliver the stored gas into the chamber of the mask device;

a first solution applicator configured to deliver a first solution directly into the first cornea, and a second solution applicator configured to deliver a second solution directly into the second cornea; and

a processor coupled to the mask device and configured to determine parameters relating to the gas delivered into the chamber of the mask device,

wherein the at least one diffuser is configured to direct gas to a first or second temple of the face, and

wherein the mask is configured for the gas to pass from the chamber through at least one of the first aperture and the second aperture.

Continuity (3)

References Cited (44)