Nucleic acid molecules encoding chimeric antigen receptors targeting B-cell maturation antigen and uses thereof

1. A nucleic acid molecule encoding a chimeric antigen receptor (CAR) comprising an extracellular antigen-binding domain that binds to a B-cell maturation antigen (BCMA), a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen-binding domain comprises:

(a) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:89, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:90, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:91; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:92, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:93, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:94;

(b) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:95, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:96, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:97; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:98, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:99, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:100;

(c) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:101, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:102, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:103; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:104, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:105, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:106;

(d) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:107, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:108, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:109; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:110, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:111, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:112;

(e) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:113, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:114, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:115; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:116, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:117, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:118;

(f) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:119, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:120, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:121; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:122, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:123, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:124;

(g) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:125, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:126, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:127; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:128, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:129, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:130;

(h) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:131, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:132, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:133; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:134, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:135, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:136;

(i) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:137, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:138, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:139; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:140, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:141, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:142;

(j) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:143, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:144, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:145; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:146, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:147, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:148;

(k) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:149, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:150, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:151; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:152, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:153, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:154;

(l) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:155, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:156, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:157; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:158, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:159, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:160;

(m) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:161, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:162, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:163; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:164, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:165, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:166;

(n) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:167, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:168, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:169; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:170, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:171, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:172;

(o) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:173, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:174, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:175; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:176, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:177, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:178;

(p) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:179, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:180, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:181; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:182, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:183, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:184; or

(q) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:185, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:186, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:187; and a light chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:188, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:189, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:190.

2. A nucleic acid molecule encoding a chimeric antigen receptor (CAR) comprising an extracellular antigen-binding domain that binds to a B-cell maturation antigen (BCMA), a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen-binding domain comprises:

(a) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:1, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:2;

(b) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:5, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:6;

(c) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:9, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:10;

(d) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:13, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:14;

(e) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:17, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:18;

(f) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:21, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:22;

(g) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:25, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:26;

(h) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:29, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:30;

(i) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:33, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:34;

(j) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:37, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:38;

(k) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:41, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:42;

(l) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:45, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:46;

(m) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:49, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:50;

(n) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:53, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:54;

(o) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:57, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:58;

(p) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:61, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:62; or

(q) a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:65, and a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:66.

3. The nucleic acid molecule of claim 1 , wherein:

(a) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:1, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:2;

(b) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:5, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:6;

(c) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:9, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:10;

(d) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:13, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:14;

(e) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:17, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:18;

(f) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:21, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:22;

(g) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:25, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:26;

(h) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:29, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:30;

(i) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:33, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:34;

(j) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:37, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:38;

(k) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:41, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:42;

(l) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:45, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:46;

(m) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:49, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:50;

(n) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:53, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:54;

(o) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:57, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:58;

(p) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:61, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:62; or

(q) the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:65, and the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:66.

4. The nucleic acid molecule of claim 1 , wherein:

(a) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:1, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:2;

(b) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:5, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:6;

(c) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:9, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:10;

(d) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:13, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:14;

(e) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:17, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:18;

(f) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:21, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:22;

(g) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:25, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:26;

(h) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:29, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:30;

(i) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:33, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:34;

(j) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:37, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:38;

(k) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:41, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:42;

(l) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:45, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:46;

(m) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:49, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:50;

(n) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:53, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:54;

(o) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:57, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:58;

(p) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:61, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:62; or

(q) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:65, and the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:66.

5. The nucleic acid molecule of claim 2 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:119, SEQ ID NO:120, and SEQ ID NO:121, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:122, SEQ ID NO:123, and SEQ ID NO:124, respectively.

6. The nucleic acid molecule of claim 2 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:167, SEQ ID NO:168, and SEQ ID NO:169, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:170, SEQ ID NO:171, and SEQ ID NO:172, respectively.

7. The nucleic acid molecule of claim 2 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:185, SEQ ID NO:186, and SEQ ID NO:187, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:188, SEQ ID NO:189, and SEQ ID NO:190, respectively.

8. The nucleic acid molecule of claim 1 , wherein the extracellular antigen-binding domain comprises a single-chain variable fragment (scFv).

9. The nucleic acid molecule of claim 2 , wherein the extracellular antigen-binding domain comprises a single-chain variable fragment (scFv).

10. The nucleic acid molecule of claim 4 , wherein the extracellular antigen-binding domain comprises a single-chain variable fragment (scFv).

11. The nucleic acid molecule of claim 8 , wherein the scFv is a human scFv.

12. The nucleic acid molecule of claim 1 , wherein the extracellular antigen-binding domain comprises the amino acid sequence set forth in SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:87, or SEQ ID NO:88.

13. The nucleic acid molecule of claim 1 , comprising the nucleotide sequence set forth in SEQ ID NO:207, SEQ ID NO:208, SEQ ID NO:209, SEQ ID NO:230, SEQ ID NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, or SEQ ID NO:235.

14. The nucleic acid molecule of claim 1 , wherein the BCMA comprises the amino acid sequence set forth in SEQ ID NO:71.

15. The nucleic acid molecule of claim 1 , wherein the extracellular antigen-binding domain binds to a non-linear epitope of BCMA.

16. The nucleic acid molecule of claim 1 , wherein the extracellular antigen-binding domain binds to BCMA with a binding affinity (K D ) of from about 1×10 −9 M to about 1×10 −8 M.

17. The nucleic acid molecule of claim 1 , wherein the intracellular signaling domain comprises a signaling domain of a CD3ζ polypeptide.

18. The nucleic acid molecule of claim 17 , wherein the intracellular signaling domain further comprises at least one co-stimulatory signaling region.

19. The nucleic acid molecule of claim 18 , wherein the at least one co-stimulatory signaling region comprises an intracellular signaling region of a CD28 polypeptide, an intracellular signaling region of a 4-1BB polypeptide, an intracellular signaling region of an OX40 polypeptide, an intracellular signaling region of an ICOS polypeptide, an intracellular signaling region of a DAP-10 polypeptide, or a combination thereof.

20. The nucleic acid molecule of claim 18 , wherein the at least one co-stimulatory signaling region comprises an intracellular signaling region of a CD28 polypeptide or an intracellular signaling region of a 4-1BB polypeptide.

21. The nucleic acid molecule of claim 17 , wherein the transmembrane domain comprises a transmembrane domain of a CD8 polypeptide, a CD28 polypeptide, a CD3ζ polypeptide, a CD4 polypeptide, a 4-1BB polypeptide, a n OX40 polypeptide, a n ICOS polypeptide, a CTLA-4 polypeptide, a PD-1 polypeptide, a LAG-3 polypeptide, a 2B4 polypeptide, a BTLA polypeptide, a synthetic peptide, or a combination thereof.

22. The nucleic acid molecule of claim 17 , wherein the transmembrane domain comprises a transmembrane domain of a CD28 polypeptide.

23. The nucleic acid molecule of claim 19 , wherein the transmembrane domain comprises a transmembrane domain of a CD8 polypeptide, a CD28 polypeptide, a CD3 ζ polypeptide, a CD4 polypeptide, a 4-1BB polypeptide, a n OX40 polypeptide, a n ICOS polypeptide, a CTLA-4 polypeptide, a PD-1 polypeptide, a LAG-3 polypeptide, a 2B4 polypeptide, a BTLA polypeptide, a synthetic peptide, or a combination thereof.

24. The nucleic acid molecule of claim 1 , wherein the transmembrane domain comprises a transmembrane domain of a CD28 polypeptide, and the intracellular signaling domain comprises a signaling domain of a CD3ζ polypeptide and at least one co-stimulatory signaling region that comprises an intracellular signaling region of a 4-1BB polypeptide.

25. The nucleic acid molecule of claim 2 , wherein the transmembrane domain comprises a transmembrane domain of a CD28 polypeptide, and the intracellular signaling domain comprises a signaling domain of a CD3ζ polypeptide and at least one co-stimulatory signaling region that comprises an intracellular signaling region of a 4-1BB polypeptide.

26. A vector comprising the nucleic acid molecule of claim 1 .

27. A host cell comprising the nucleic acid molecule of claim 1 .

28. The host cell of claim 27 , wherein the host cell is a T cell.

29. A method for producing a cell that binds to a B-cell maturation antigen (BCMA), comprising introducing into the cell the nucleic acid molecule of claim 1 .

30. The method of claim 29 , wherein the cell is a T cell.