Bicyclic compounds

1. A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:

wherein,

X 1 is CR X ; and each X 2 and X 3 is CR Y ;

each X 4 , X 5 , and X 6 , is independently N or CR X ;

each R X is independently hydrogen, halogen, nitro, —OR 3 , —SR 3 , —CN, —C(═O)R 3 , —C(═O)N(R 3 ) 2 , —C(═O)OR 3 , —S(═O)R 3 , —S(═O) 2 R 3 , —N(R 3 ) 2 , —NR 3 S(═O) 2 R 3 , —NR 3 C(═O)R 3 , —NR 3 C(═O)OR 3 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 2 -C 4 alkenyl, substituted or unsubstituted C 2 -C 4 alkynyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 3 -C 10 cycloalkyl, substituted or unsubstituted C 2 -C 10 heterocycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each R Y is independently hydrogen, halogen, nitro, —CN, —C(═O)R 3 , —C(═O)N(R 3 ) 2 , —C(═O)OR 3 , —S(═O)R 3 , —S(═O) 2 R 3 , —N(R 3 ) 2 , —NR 3 S(═O) 2 R 3 , —NR 3 C(═O)R 3 , —NR 3 C(═O)OR 3 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 2 -C 4 alkenyl, substituted or unsubstituted C 2 -C 4 alkynyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 3 -C 10 cycloalkyl, substituted or unsubstituted C 2 -C 10 heterocycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R is halogen, nitro, —CN, —OR 3 , —SR 3 , —C(═O)R 3 , —C(═O)N(R 3 ) 2 , —C(═O)OR 3 , —S(═O)R 3 , —S(═O) 2 R 3 , —N(R 3 ) 2 , —NR 3 S(═O) 2 R 3 , —NR 3 C(═O)R 3 , —NR 3 C(═O)OR 3 , or substituted or unsubstituted C 1 -C 6 fluoroalkyl;

R 1 is C 1 -C 6 alkyl substituted with —OR 3 ; and R 3 is hydrogen, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, or substituted or unsubstituted C 3 -C 10 cycloalkyl;

each R 2 is independently halogen, nitro, —N 3 , —CN, —OR 3 , —SR 3 , —S(═O) 2 R 3 , —N(R 3 ) 2 , —C(═O)OR 3 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 3 -C 10 cycloalkyl, substituted or unsubstituted C 2 -C 10 heterocycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each R 3 is independently hydrogen, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 3 -C 10 cycloalkyl, substituted or unsubstituted C 2 -C 10 heterocycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or if two R 3 are on the same nitrogen atom, then two R 3 are taken together with the nitrogen atom to which they are attached to form a substituted or unsubstituted C 3 -C 7 heterocycloalkyl; and

n is 0, 1, 2, 3, or 4.

2. The compound or pharmaceutically acceptable salt or solvate thereof of claim 1 , wherein:

R is —CF 3 ; and

n is 0.

3. The compound or pharmaceutically acceptable salt or solvate thereof of claim 1 , wherein:

each X 4 , X 5 , and X 6 is CR X ;

or X 4 is N; and each X 5 and X 6 is CR X ;

or X 4 and X 5 is CR X ; and X 6 is N;

each R X is independently hydrogen, F, Cl, Br, —CH 3 , —OH, —OCH 3 , or —OCF 3 ; and

each R Y is hydrogen.

4. The compound or pharmaceutically acceptable salt or solvate thereof of claim 3 , wherein:

R 1 is C 1 -C 6 alkyl substituted with —OR 3 ; and R 3 is hydrogen or unsubstituted C 1 -C 6 alkyl;

R is —CF 3 ; and

n is 0.

5. The compound or pharmaceutically acceptable salt or solvate thereof of claim 1 , wherein the compound has one of the following structures:

pharmaceutically acceptable salt thereof.