Dermal compositions
Disclosed herein are veterinary compositions including imidacloprid or an analogue thereof; a pyrethroid; a solvent selected from the group consisting of N-methyl pyrrolidone, N-ethyl pyrrolidone and mixtures thereof; and dimethyl sulfoxide. The veterinary compositions of the invention are useful in methods of controlling parasites on or within warm-blooded domesticated animals.
1. A method of controlling parasites on a warm-blooded animal comprising:
applying to skin of an animal to be treated, a veterinary composition comprising:
2.5% to 12.5% by weight of imidacloprid or an analogue thereof;
35% to 67.5% by weight of permethrin;
0.1% to 2% by weight of pyriproxyfen;
a first solvent of 21% to 23% by weight, selected from the group consisting of N-methyl pyrrolidone, N-ethyl pyrrolidone and mixtures thereof; and
a second solvent of 15% to less than 20% by weight of dimethyl sulfoxide (DMSO).
2. The method according to claim 1 , wherein the parasites are selected from the group consisting of ectoparasites, endoparasites or both.
3. The method according to claim 1 , wherein the parasites are selected from one or more of the groups consisting of fleas, ticks, mites, lice, intestinal worms, and heartworms.
4. The method according to claim 1 , wherein the animal is a dog.
5. The method according to claim 1 , wherein the second solvent of the veterinary composition is 17% to 19% by weight of DMSO.
6. The method according to claim 1 , wherein the first solvent of the veterinary composition is N-methyl pyrrolidone.
7. The method according to claim 1 , wherein the first solvent of the veterinary composition is N-ethyl pyrrolidone.
8. The method according to claim 1 , wherein the veterinary composition further comprises an antioxidant in an amount in the range from about 0.05% to about 0.25% by weight.
9. The method according to claim 1 , wherein the veterinary composition further comprises at least one organic acid in an amount in the range from about 0.05% to about 1% by weight.