Cartilage mimetic gels
A cartilage mimetic gel includes double network hydrogels. The double network hydrogels comprise a first crosslinked network and a second crosslinked network. The first crosslinked network can be formed from poly(2-acrylamido-2-methylpropane sulfonic acid). The second crosslinked network can be formed from poly(N-isopropyl acrylamide-co-acrylamide).
1. A cartilage mimetic gel comprising:
double network hydrogels,
wherein the double network hydrogels comprise a first crosslinked network formed from poly(2-acrylamido-2-methylpropane sulfonic acid) and a second crosslinked network.
2. The cartilage mimetic gel of claim 1 , wherein the second crosslinked network is formed from poly(N-isopropyl acrylamide-co-acrylamide).
3. The cartilage mimetic gel of claim 1 , wherein at least one of the first crosslinked network and the second crosslinked network comprises a comonomer.
4. The cartilage mimetic gel of claim 1 , wherein the double network hydrogels comprise a comonomer selected from the group consisting of a zwitterionic comonomer, a hydrophilic comonomer, a neutral comonomer, an anionic comonomer, a cationic comonomer, or combinations thereof.
5. The cartilage mimetic gel of claim 1 , further comprising a third crosslinked network that comprises at least one of a zwitterionic comonomer, a hydrophilic comonomer, a neutral comonomer, an anionic comonomer, a cationic comonomer, or combinations thereof.
6. The cartilage mimetic gel of claim 1 , wherein the double network hydrogels are porated.
7. The cartilage mimetic gel of claim 1 , wherein the double network hydrogels are coated with polydopamine.
8. The cartilage mimetic gel of claim 1 , wherein the double network hydrogels combined with an anchoring base.
9. The cartilage mimetic gel of claim 8 , wherein the anchoring base is at least one of a regenerative polymeric scaffold, a metal, a ceramic, and an alloy.
10. A cartilage mimetic gel comprising:
double network hydrogels,
wherein the double network hydrogels comprise a first crosslinked network formed from poly(N-isopropyl acrylamide-co-acrylamide) and a second crosslinked network.
11. The cartilage mimetic gel of claim 10 , wherein the second crosslinked network is formed from poly(2-acrylamido-2-methylpropane sulfonic acid).
12. The cartilage mimetic gel of claim 10 , wherein at least one of the first crosslinked network and the second crosslinked network comprises a comonomer.
13. The cartilage mimetic gel of claim 10 , wherein the double network hydrogels comprise a comonomer selected from the group consisting of a zwitterionic comonomer, a hydrophilic comonomer, a neutral comonomer, an anionic comonomer, a cationic comonomer, or combinations thereof.
14. The cartilage mimetic gel of claim 10 , further comprising a third crosslinked network that comprises at least one of a zwitterionic comonomer, a hydrophilic comonomer, a neutral comonomer, an anionic comonomer, a cationic comonomer, or combinations thereof.
15. The cartilage mimetic gel of claim 10 , wherein the double network hydrogels are porated.
16. The cartilage mimetic gel of claim 10 , wherein the double network hydrogels are coated with polydopamine.
17. The cartilage mimetic gel of claim 10 , wherein the double network hydrogels combined with an anchoring base.
18. The cartilage mimetic gel of claim 17 , wherein the anchoring base is at least one of a regenerative polymeric scaffold, a metal, a ceramic, and an alloy.