RAPID SKIN TREATMENT USING MICROCORING
Described herein are technologies, methods, and/or devices for treating skin (e.g., eliminating tissue volume, tightening skin, lifting skin, and/or reducing skin laxity) by selectively excising a plurality of microcores without thermal energy being imparted to surrounding (e.g., non-excised) tissue. In certain embodiments, excising is completed within a certain time or is performed at a certain rate. In certain embodiments, treatment is performed in specific areas not treatable with thermal methods, e.g., in the vicinity of nerves and/or other heat sensitive areas. In certain embodiments, a cosmetic effect is visible immediately or within a very short time after completion of treatment.
1 . A method comprising steps of:
excising a plurality of microcores from a site on a surface of a human subject, wherein each of the microcores is characterized by a diameter of between 0.1 mm and 1.0 mm, and/or a volume of between 0.001 mm 3 and 6.3 mm 3 , wherein the excising is completed within a time period between 1 minute and 2 hours.
2 . A method comprising steps of:
excising a plurality of microcores from a site on a surface of a human subject, wherein each of the microcores is characterized by a diameter of between 0.1 mm and 1.0 mm, and a volume of between 0.001 mm 3 and 6.3 mm 3 , wherein the excising is performed at a rate of between 100 to 30,000 cores/minute.
3 . The method of claim 1 , wherein the step of excising comprises sequestering the excised microcores, and the method further comprises discarding the sequestered microcores or using them for diagnostics.
4 . The method of claim 1 , wherein the plurality of microcores comprises at least 1,500 microcores.
5 . The method of claim 1 , wherein the surface is selected from the group consisting of the face, eyelid, cheeks, chin, forehead, lips, or nose, neck, chest, arms, hands, legs, abdomen, buttock, and thigh.
6 . The method of claim 1 , wherein a length of the micorcore is sufficient to obtain a full thickness core.
7 . The method of claim 1 , wherein a length of the micorcore is sufficient to extend into the subcutaneous fat layer.
8 . The method of claim 1 , wherein the time period is between 6 minutes and 45 minutes.
9 . The method as in any one of claim 2 , wherein the rate is between about 240 and about 2,000 cores/minute.
10 . The method as in any one of claim 2 , wherein the rate is between about 260 and about 1,000 cores/minute.
11 . The method of claim 1 , wherein the surface is the face and the time period is between 15 minutes and 30 minutes.
12 . The method of claim 1 , wherein the area or volumetric fraction of tissue excised from the site is 10% of the area of the site.
13 . The method of claim 1 , wherein the microcores are excised without excising the epidermal layer.
14 . The method of claim 1 , wherein the site is pre-treated prior to receiving treatment using microcoring, wherein the pre-treatment comprises elevating and/or stretching the skin.
15 . The method of claim 1 , wherein the method comprises determining the presence of a nerve beneath the surface of a site prior to removing/excising a microcore.
16 . The method of claim 1 , wherein the site is a heat-sensitive site or a light/UV-sensitive site.
17 . The method of claim 1 , wherein the site is located on the face in close proximity to an eye, or is located in close proximity to the facial nerve or a facial nerve branch.
18 . The method of claim 1 , wherein the site is located over an area that comprises a mechanical implant, a dermal filler, or a breast implant, or is located near a thyroid gland, thyroid cartilage, trachea, a major blood vessel, or breast tissue.
19 . The method of claim 1 , wherein the method comprises separating the dermal layer from the superficial muscular aponeurotic system (SMAS) layer.
20 . The method of claim 1 , wherein the subject has been treated with ultrasound therapy, laser therapy, radiofrequency, botox, dermafillers, or cosmetic surgery prior to receiving treatment using microcoring.
21 . The method of claim 1 , wherein the subject is between 40-70 years of age; has Fitzpatrick Skin Type 1, 2, or 3; has re-auricular wrinkle severity graded as ≥2 and/or one or more of the following: Nasolabial fold severity at rest ≥2 and ≤4; Marionette line prominence at rest ≥2 and ≤4; Oral commissure drooping at rest ≥2 and ≤4; or Jawline sagging at rest ≥2 and ≤4.
22 . The method of claim 1 , wherein the subject has Fitzpatrick Skin Type 4, 5, or 6.
23 . The method of claim 1 , wherein the subject, on Day 3 post treatment, experiences ecchymosis, tenderness, pruritis, erythema/inflammation, crusting, hyper pigmentation, hypo pigmentation, swelling/fluid accumulation, and/or bleeding at an average severity level of below 1.5 (on 0-4 severity scale), and wherein the subject exhibits no appearance of scarring.
24 . The method of claim 1 , wherein the subject, on Day 5 post treatment, experiences ecchymosis, tenderness, pruritis, erythema/inflammation, crusting, hyper pigmentation, hypo pigmentation, swelling/fluid accumulation, and/or bleeding at an average severity level of below 1.5 (on 0-4 severity scale), and wherein the subject exhibits no appearance of scarring.
25 . The method of claim 1 , wherein the subject, on Day 7 post treatment, experiences a global aesthetic improvement scale (GAIS) score of at least 3 (Improved).
26 . The method of claim 1 , wherein the subject, on Day 7 post treatment, has re-auricular wrinkle severity improved by at least 1 level; Nasolabial fold severity at rest improved by at least 1 level; Marionette line prominence at rest improved by at least 1 level; Oral commissure drooping at rest improved by at least 1 level; or Jawline sagging at rest improved by at least 1 level.
27 . The method of claim 1 , wherein the subject, 6 months post treatment, has re-auricular wrinkle severity improved by at least 1 level; Nasolabial fold severity at rest improved by at least 1 level; Marionette line prominence at rest improved by at least 1 level; Oral commissure drooping at rest improved by at least 1 level; or Jawline sagging at rest improved by at least 1 level.
28 . The method of claim 1 , wherein a cosmetic effect is first detectable during treatment, or immediately after completion of treatment, or 1 min, 5 min, 10 min, 20 min, 30 min, 1 hour, 2 hours, 3 hours, 6 hours, 12 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, 4 months, 5 months, or 6 months after completion of treatment.
29 . The method of claim 28 , wherein the cosmetic effect is cosmetic skin tightening.
30 . The method of claim 29 , wherein the cosmetic skin tightening is detectable within a time period no longer than 7 days after completion of treatment.