USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS
The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing an alcohol-related or addictive disorder. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (−)-enantiomer
1 . A method for treating or preventing an alcohol-related or addictive disorder alleviated comprising administering to a patient in need of such treatment or prevention an effective amount of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, each being substantially free of its corresponding (−)-enantiomer.
2 . The method according to claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof has no more than about 2% w/w of the corresponding (−)-enantiomer.
3 . The method according to claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof has no more than about 1% w/w of the corresponding (−)-enantiomer.
4 . The method according to claim 1 , wherein said (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof is effective to reduce alcohol consumption by said patient in comparison to a control subject that does not receive said (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof.
5 . The method according to claim 1 , wherein said alcohol-related disorder is selected from the group consisting of Alcohol-Induced Psychotic Disorder, with delusions; Alcohol Abuse; Alcohol Intoxication; Alcohol Withdrawal; Alcohol Intoxication Delirium; Alcohol Withdrawal Delirium; Alcohol-Induced Persisting Dementia; Alcohol-Induced Persisting Amnestic Disorder; Alcohol Dependence; Alcohol-Induced Psychotic Disorder, with hallucinations; Alcohol-Induced Mood Disorder; Alcohol-Induced Anxiety Disorder; Alcohol-Induced Sexual Dysfunction; Alcohol-Induced Sleep Disorders; Alcohol-Related Disorders not otherwise specified (NOS); and Alcohol Intoxication.
6 . The method according to claim 1 , wherein the addictive disorder is selected from the group consisting of eating disorders, impulse control disorders, nicotine-related disorders, amphetamine-related disorders, cannabis-related disorders, cocaine-related disorders, hallucinogen-use disorders, inhalant-related disorders, and opioid-related disorders.
7 . The method according to claim 1 further comprising administering another therapeutic agent.
8 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-alcohol agent.
9 . The method according to claim 8 wherein said anti-alcohol agent is selected from the group consisting of disulfram, naltrexone, acamprosate, ondansetron, sertraline, galanthamine, nalmefene, naloxone, desoxypeganine, benzodiapenes, neuroleptics, risperidone, remonabant, trazaodone, topiramate, and aripiprazole.
10 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-nicotine agent.
11 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-opiate agent.
12 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-cocaine agent.
13 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-depressant.
14 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-psychotic drug.
15 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anxiolytic agent.
16 . The method according to claim 7 , wherein the wherein the other therapeutic agent is an anti-alcohol agent.
17 . A method for treating or preventing ethanol consumption comprising administering to a patient in need of such treatment or prevention an effective amount (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, each being substantially free of its corresponding (−)-enantiomer
18 . The method according to claim 17 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof has no more than about 2% w/w of the corresponding (−)-enantiomer.
19 . The method according to claim 17 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof has no more than about 1% w/w of the corresponding (−)-enantiomer.
20 . The method according to claim 17 further comprising administering another therapeutic agent.
21 . The method according to claim 20 , wherein the wherein the other therapeutic agent is an anti-alcohol agent.
22 . The method according to claim 21 wherein said anti-alcohol agent is selected from the group consisting of disulfram, naltrexone, acamprosate, ondansetron, sertraline, galanthamine, nalmefene, naloxone, desoxypeganine, benzodiapenes, neuroleptics, risperidone, remonabant, trazaodone, topiramate, and aripiprazole.
23 . A method for treating or preventing an alcohol-related or addictive disorder alleviated comprising administering to a patient in need of such treatment or prevention an effective amount of unbalanced triple reuptake inhibitor having a serotonin-norepinephrine-dopamine reuptake inhibition ratio ranging from about 1-2:1-3:4-12 or a pharmaceutically acceptable salt thereof.