IP Library Granted Patent US 11,555,053
Granted Patent B2
US 11,555,053 · App. 16/866,164 · Granted Jan 17, 2023

Crystalline salt forms

Inventors: Scott M. Duncan (Bedford, MA); Martin P. Redmon (Boston, MA)
Assignee: Stealth BioTherapeutics Inc.
C07K5/0817A61K38/00C07B2200/13
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Quick Facts
Patent No.
US 11,555,053
App. No.
16/866,164
Granted
Jan 17, 2023
Kind
B2
Abstract

Disclosed are various crystalline salt forms of D-Arg-Dmt-Lys-Phe-NH 2 .

Claims (12)

1. A crystalline form of a mesylate salt of Compound I,

wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 6.0, 10.4, 11.0, 12.0, 14.9, 19.3, 20.4, and 21.4.

2. The crystalline form of claim 1 , wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 6.0, 10.4, 11.0, 12.0, 14.9, 15.7, 18.8, 19.3, 20.4, 20.8, 21.2, 21.4, 21.6, 22.0, 22.5, 22.9, 25.9, and 26.4.

3. A crystalline form of a mesylate salt of Compound I,

wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 3.2, 4.3, 6.0, 12.8, 17.5, 18.9, 20.6, 21.4, and 22.7.

4. The crystalline form of claim 3 , wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 3.2, 4.3, 6.0, 12.0, 12.4, 12.8, 14.6, 15.8, 15.9, 17.5, 18.4, 18.9, 19.4, 19.8, 20.1, 20.6, 21.4, 22.7, 23.2, 23.8, 24.8, 25.4, and 26.1.

5. A composition, comprising a crystalline form of claim 1 .

6. A process for making a pharmaceutical composition comprising Compound I,

comprising dissolving a crystalline form of claim 1 .

7. A composition, comprising a crystalline form of claim 3 .

8. A process for making a pharmaceutical composition comprising Compound I,

comprising dissolving a crystalline form of claim 3 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2021
From: STEALTH BIOTHERAPEUTICS CORP.
To: STEALTH BIOTHERAPEUTICS INC.
Reel/Frame 058601/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2021
From: DUNCAN, SCOTT M.; REDMON, MARTIN P.
To: STEALTH BIOTHERAPEUTICS CORP.
Reel/Frame 056126/0177 →
Continuity (3)
Continuation 16084168
Provisional Application 62307095 · Mar 11, 2016
Related Publication 20210047368A1 · Feb 18, 2021
Cited By (1)
US 12,252,553