Granted Patent
B2
US 12,378,286 · App. 16/866,308 · Granted Aug 5, 2025
Methods and compositions useful for inhibiting growth of certain bacteria
Inventors:
Asaf Levy (Concord, CA); Maximilian Mittelviefhaus (Zurich, CH); Jiamin Miao (Lanzhou, CN); Kunru Wang (Blacksburg, VA); Bingyu Zhao (Blacksburg, VA); Julia Vorholt-Zambelli (Zurich, CH); Jeffrey L. Dangl (Chapel Hill, NC)
Assignees:
The Regents of the University of California; ETH-Zurich; Virginia Tech Intellectual Properties, Inc.; The University of North Carolina at Chapel Hill
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Abstract
The present invention provides for a composition comprising a purified or isolated Hyde1 gene product, or a functional fragment thereof; a modified host cell capable of expressing a Type VI secretion system (T6SS), Hyde1, and/or Hyde2, or a functional fragment thereof; a method of treating a disease caused all or in part by a bacterial cell, comprising administering a composition of the present invention to a subject in need thereof; and a method to limit or reduce growth of a pathogenic bacteria in an environment, comprising: introducing a non-pathogenic bacterial capable of expressing a Type VI secretion system (T6SS), Hyde1, and/or Hyde2, or functional fragment thereof, to an environment.
Claims (1)
1. A method of treating a disease caused all or in part by a Escherichia coli cell, comprising: administering a pharmaceutical composition comprising a purified or isolated Hyde1 gene product and a pharmaceutically acceptable carrier to a subject in need thereof; wherein the Hyde1 gene product is SEQ ID NO:1, and the Escherichia coli cell is a human pathogen and the subject is a human patient.
Assignments (6)
CONFIRMATORY LICENSE
Recorded Dec 16, 2020
From: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 054774/0328 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 5, 2020
From: LEVY, ASAF
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 052575/0889 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 5, 2020
From: DANGL, JEFFREY L.
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 052576/0104 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 5, 2020
From: VORHOLT-ZAMBELLI, JULIA; MITTELVIEFHAUS, MAXIMILIAN
To: ETH ZURICH
Reel/Frame 052576/0454 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 5, 2020
From: WANG, KUNRU; ZHAO, BINGYU; MIAO, JIAMIN
To: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY
Reel/Frame 052576/0674 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 5, 2020
From: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY
To: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Reel/Frame 052576/0849 →
Continuity (3)
Continuation
PCTUS2018059277
· Nov 5, 2018
Provisional Application
62581556
· Nov 3, 2017
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