Macrocyclic compounds for treating disease
The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
1. A compound having structure:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 having structure
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 having structure
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 having structure
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 having structure
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 having structure
or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a diluent, carrier or excipient.
8. A method of ameliorating a cancer in a human in need thereof, comprising administering to the human an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the cancer is selected from thyroid cancer, lung cancer, colon cancer, breast cancer, prostate cancer, hepatocellular carcinoma, and head and neck cancer.
9. The method of claim 8 , wherein the cancer is thyroid cancer.
10. The method of claim 8 , wherein the cancer is lung cancer.
11. The method of claim 8 , wherein the cancer is colon cancer.
12. The method of claim 8 , wherein the cancer is breast cancer.
13. The method of claim 8 , wherein the cancer is prostate cancer.
14. The method of claim 8 , wherein the cancer is hepatocellular carcinoma.
15. The method of claim 8 , wherein the cancer is head and neck cancer.