Metabolically stable vanillin derivatives for the treatment of hypoxia
Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
1. A method of enhancing oxygen delivery from hemoglobin to hypoxic tissue by administering to a subject a therapeutically effective amount of a compound, or pharmaceutically acceptable salt or solvate thereof, selected from the group consisting of
2. The method of claim 1 wherein said therapeutically effective amount of said compound is sufficient to inhibit red blood cell (RBC) sickling.
3. The method of claim 1 wherein the compound, or pharmaceutically acceptable salt or solvate thereof is one of
4. The method of claim 1 wherein the compound, or pharmaceutically acceptable salt or solvate thereof is one of