Regulating a detector flow of a field flow fractionator

1. An apparatus comprising:

a detector flow meter,

wherein an inlet of the detector flow meter is configured to be connected to an outlet of a detector chain comprising at least one detector,

wherein an inlet of the detector chain is connected to the outlet of a detector port of a field flow fractionator,

wherein the detector flow meter is configured to measure a detector flow from the field flow fractionator;

a channel pressure meter,

wherein an inlet of the channel pressure meter is configured to be connected to an outlet of a split port of the field flow fractionator,

wherein the channel pressure meter is configured to measure a channel pressure of the field flow fractionator;

at least one control valve,

wherein an inlet of the at least one control valve is connected to an outlet of the channel pressure meter;

wherein the detector flow meter is configured to set a channel pressure set point of the channel pressure meter to maintain the detector flow from the detector port at a particular flow rate; and

wherein the channel pressure meter is configured to actuate the at least one control valve to maintain a channel pressure of the field flow fractionator at the channel pressure set point.

2. The apparatus of claim 1 wherein the at least one detector is one of a light scattering instrument, a viscometer, a refractometer, an ultraviolet-visible absorption detector, an infrared absorption detector, an evaporative light scattering detector, a Raman spectroscopy detector, an inductively coupled plasma mass spectrometry, a fluorescence detector, a conductivity detector, and a pH detector.

3. The apparatus of claim 2 wherein the light scattering instrument is one of a static light scattering instrument and a dynamic light scattering instrument.

4. The apparatus of claim 1 wherein the field flow fractionator (FFF) comprises at least one of an asymmetric flow FFF system, a gravitational FFF system, a centrifugal FFF system, a thermal-gradient FFF system, an electrical FFF system, a magnetic FFF system, a flow FFF system, a hollow fiber FFF system, and a split flow thin-cell fractionation system.

5. The apparatus of claim 1 wherein the particular flow rate is a constant flow rate.

6. The apparatus of claim 1 wherein the channel pressure meter is configured to actuate the at least one control valve to maintain the detector flow at the particular flow rate at a set time.

7. The apparatus of claim 6

wherein the channel pressure meter is configured to actuate the at least one control valve towards a closed state to increase the channel pressure, in response to the detector flow being less than the particular flow rate, and

wherein the channel pressure meter is configured to actuate the at least one control valve towards an open state to decrease the channel pressure, in response to the detector flow being greater than the particular flow rate.

8. The apparatus of claim 1

wherein the channel pressure meter is configured to actuate the at least one control valve towards a closed state to increase the channel pressure, and

wherein the channel pressure meter is configured to actuate the at least one control valve towards an open state to decrease the channel pressure.

9. The apparatus of claim 1 wherein an outlet of the detector flow meter is configured to be connected to a fraction collector.

10. A computer implemented method comprising:

receiving, by a computer system, detector flow data from a detector flow meter,

wherein the detector flow meter is configured to measure a detector flow from a field flow fractionator,

wherein an inlet of the detector flow meter is configured to be connected to an outlet of a detector chain comprising at least one detector,

wherein an inlet of the detector chain is connected to the outlet of a detector port of the field flow fractionator;

receiving, by the computer system, channel pressure data from a channel pressure meter,

wherein the channel pressure meter is configured to measure a channel pressure of the field flow fractionator,

wherein an inlet of the channel pressure meter is configured to be connected to an outlet of a split port of the field flow fractionator;

executing, by the computer system, in response to the received detector flow data, a set of logical operations setting, via the detector flow meter, a channel pressure set point of the channel pressure meter to maintain the detector flow from the detector port at a particular flow rate; and

executing, by the computer system, in response to the received channel pressure data, a set of logical operations actuating, via the channel pressure meter, at least one control valve to maintain a channel pressure of the field flow fractionator at the channel pressure set point,

wherein an inlet of the at least one control valve is connected to an outlet of the channel pressure meter.

11. The method of claim 10 wherein the at least one detector is one of a light scattering instrument, a viscometer, a refractometer, an ultraviolet-visible absorption detector, an infrared absorption detector, an evaporative light scattering detector, a Raman spectroscopy detector, an inductively coupled plasma mass spectrometry, a fluorescence detector, a conductivity detector, and a pH detector.

12. The method of claim 10 wherein the particular flow rate is a constant flow rate.

13. The method of claim 10 wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve to maintain the detector flow at the particular flow rate at a set time.

14. The method of claim 13

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards a closed state to increase the channel pressure, in response to the detector flow being less than the particular flow rate, and

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards an open state to decrease the channel pressure, in response to the detector flow being greater than the particular flow rate.

15. The method of claim 10

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards a closed state to increase the channel pressure, and

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards an open state to decrease the channel pressure.

16. A system comprising:

a memory; and

a processor in communication with the memory, the processor configured to perform a method comprising

receiving detector flow data from a detector flow meter,

wherein the detector flow meter is configured to measure a detector flow from a field flow fractionator,

wherein an inlet of the detector flow meter is configured to be connected to an outlet of a detector chain comprising at least one detector,

wherein an inlet of the detector chain is connected to the outlet of a detector port of the field flow fractionator,

receiving channel pressure data from a channel pressure meter,

wherein the channel pressure meter is configured to measure a channel pressure of the field flow fractionator,

wherein an inlet of the channel pressure meter is configured to be connected to an outlet of a split port of the field flow fractionator,

executing, in response to the received detector flow data, a set of logical operations setting, via the detector flow meter, a channel pressure set point of the channel pressure meter to maintain the detector flow from the detector port at a particular flow rate, and

executing, in response to the received channel pressure data, a set of logical operations actuating, via the channel pressure meter, at least one control valve to maintain a channel pressure of the field flow fractionator at the channel pressure set point,

wherein an inlet of the at least one control valve is connected to an outlet of the channel pressure meter.

17. The system of claim 16 wherein the particular flow rate is a constant flow rate.

18. The system of claim 16 wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve to maintain the detector flow at the particular flow rate at a set time.

19. The system of claim 18

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards a closed state to increase the channel pressure, in response to the detector flow being less than the particular flow rate, and

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards an open state to decrease the channel pressure, in response to the detector flow being greater than the particular flow rate.

20. The system of claim 16

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards a closed state to increase the channel pressure, and

wherein the actuating comprises actuating, via the channel pressure meter, the at least one control valve towards an open state to decrease the channel pressure.