IP Library › Granted Patent US 10,844,042
Granted Patent B2
US 10,844,042 · App. 16/878,421 · Granted Nov 24, 2020

Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use

Inventors: Robert J. Altenbach (Chicago, IL); Andrew Bogdan (Evanston, IL); Sylvain Couty (Gentilly, FR); Nicolas Desroy (Massy, FR); Gregory A. Gfesser (Lindenhurst, IL); Christopher Gaëtan Housseman (Montreuil, FR); Philip R. Kym (Libertyville, IL); Bo Liu (Waukegan, IL); Thi Thu Trang Mai (Romainville, FR); Karine Fabienne Malagu (Saffron Walden, GB); Nuria Merayo Merayo (Paris, FR); Olivier Laurent Picolet (Romainville, FR); Mathieu Rafaël Pizzonero (Voisins le Bretonneaux, FR); Xenia B. Searle (Grayslake, IL); Steven Emiel Van der Plas (Steenhuffel, BE); Xueqing Wang (San Carlos, CA); Ming C. Yeung (Grayslake, IL)
Assignees: AbbVie Overseas S.à.r.l.; Galapagos NV
C07D401/04A61P1/00A61P11/00C07C311/45C07D213/30C07D213/64C07D213/71C07D215/36C07D231/56C07D235/28C07D401/12C07D401/14C07D471/04
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Quick Facts
Patent No.
US 10,844,042
App. No.
16/878,421
Granted
Nov 24, 2020
Kind
B2
Abstract

The invention discloses compounds of Formula (I), wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Claims (2)

1. 1-{5-cyclopropyl-2-[(propan-2-yl)oxy]pyridin-3-yl}-N-(2-methylquinoline-5-sulfonyl)cyclopropane-1-carboxamide.

2. 1-{5-cyclopropyl-2-[(propan-2-yl)oxy]pyridin-3-yl}-N-(2-methylquinoline-5-sulfonyl)cyclopropane-1-carboxamide or a pharmaceutically acceptable salt thereof.

Assignments (8)
MERGER Recorded Mar 15, 2023
From: ABBVIE GLOBAL LIMITED
To: ABBVIE GLOBAL ENTERPRISES LTD.
Reel/Frame 062990/0546 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2023
From: ABBVIE OVERSEAS S.Á.R.L.
To: ABBVIE GLOBAL LIMITED
Reel/Frame 063100/0515 →
MERGER Recorded Aug 12, 2020
From: ABBVIE S.À.R.L.
To: ABBVIE OVERSEAS S.À.R.L.
Reel/Frame 053480/0787 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 12, 2020
From: ALTENBACH, ROBERT; BOGDAN, ANDREW; GFESSER, GREGORY A.; KYM, PHILIP R.; LIU, BO; SEARLE, XENIA; WANG, XUEQING; YEUNG, MING CLINTON
To: ABBVIE S.Á.R.L.
Reel/Frame 053477/0687 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 12, 2020
From: ALTENBACH, ROBERT; BOGDAN, ANDREW; GFESSER, GREGORY A.; KYM, PHILIP R.; LIU, BO; SEARLE, XENIA; WANG, XUEQING; YEUNG, MING CLINTON
To: ABBVIE S.Á.R.L.
Reel/Frame 053477/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2020
From: DESROY, NICOLAS; HOUSSEMAN, CHRISTOPHER GAËTEN; MERAYO MERAYO, NURIA; PIZZONERO, MATHIEU RAFAËL; PICOLET, OLIVIER LAURENT; COUTY, SYLVAIN; MAI, THI THU TRANG
To: GALAPAGOS SASU
Reel/Frame 053023/0551 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2020
From: MALAGU, KARINE FABIENNE
To: CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED
Reel/Frame 053023/0749 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2020
From: VAN DER PLAS, STEVEN EMIEL; GALAPAGOS SASU; CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED
To: GALAPAGOS NV
Reel/Frame 053023/0815 →
Continuity (4)
Continuation 16129458 · Sep 12, 2018
Provisional Application 62608846 · Dec 21, 2017
Provisional Application 62558430 · Sep 14, 2017
Related Publication 20200277274A1 · Sep 3, 2020