Systems and methods for assessment of contact quality
Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.
1. A method for monitoring tissue ablation comprising:
receiving a tissue fluorescence signal indicative of fluorescence in a tissue being ablated by an ablation device contacting the tissue to deliver ablation energy to the tissue; and
displaying an amplitude of the tissue fluorescence signal during the delivery of the ablation energy, wherein the amplitude of the tissue fluorescence signal is indicative of a stability of a contact between the ablation device and the tissue.
2. The method of claim 1 , further comprising monitoring the amplitude of the tissue fluorescence signal during the delivery of the ablation energy to confirm that the ablation device remains in contact with the tissue, and stopping ablation of the tissue when the contact between the ablation device and the tissue is not stable.
3. The method of claim 1 , wherein the tissue is illuminated with light having a wavelength between about 300 nm and about 400 nm to excite the tissue fluorescence in the tissue.
4. The method of claim 1 , wherein the ablation energy is selected from the group consisting of radiofrequency (RF) energy, microwave energy, electrical energy, electromagnetic energy, cryoenergy, laser energy, ultrasound energy, acoustic energy, chemical energy, thermal energy, electroporation energy and combinations thereof.
5. The method of claim 1 , wherein the ablation device is located at a distal tip of catheter, the catheter further comprising a catheter comprising a catheter body; and one or more optical fibers extending through the catheter body into the illumination cavity of the distal tip, the one or more optical fibers being in communication with a light source and a light measuring instrument to illuminate the tissue and to relay light energy reflected from the tissue to the light measuring instrument.
6. The method of claim 1 , further comprising determining a normalized magnitude of the amplitude of the tissue fluorescence signal and displaying variations in a magnitude of the amplitude of the tissue fluorescence signal to the normalized magnitude of the amplitude of the tissue fluorescence signal.
7. The method of claim 6 , wherein the variations in magnitude are used to determine stability of contact between the ablation device and the tissue.
8. The method of claim 1 , wherein the tissue fluorescence is detected between about 375 nm and about 575 nm.
9. The method of claim 1 , wherein the tissue fluorescence is in the form of nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence.
10. A system for monitoring tissue ablation comprising:
a processor in communication with a light measuring instrument, the processor being programmed to:
receive tissue fluorescence data from the tissue during the delivery of ablation energy to the tissue by an ablation device;
generate a tissue fluorescence signal from the tissue fluorescence data; and
display the amplitude of an tissue fluorescence signal during the delivery of ablation energy, wherein the amplitude of the tissue fluorescence signal is indicative of a stability of a contact between the ablation device and the tissue.
11. The system of claim 10 , wherein the processor is programmed to monitor the amplitude of the tissue fluorescence signal during the delivery of ablation energy to confirm that the ablation device remains in contact with the tissue.
12. The system of claim 10 , wherein the ablation energy is selected from the group consisting of radiofrequency (RF) energy, microwave energy, electrical energy, electromagnetic energy, cryoenergy, laser energy, ultrasound energy, acoustic energy, chemical energy, thermal energy, electroporation energy and combinations thereof.
13. The system of claim 10 , wherein the processor is programmed to determine a normalized magnitude of the amplitude of the tissue fluorescence signal and to display variations in a magnitude of the amplitude of the tissue fluorescence signal to the normalized magnitude of the amplitude of the tissue fluorescence signal, wherein the variations in magnitude are used to determine stability of contact between the distal tip and the tissue.
14. A system for monitoring tissue ablation comprising:
an ablation system for delivering ablation energy to a tissue;
a visualization system comprising a light source, a light measuring instrument, and one or more optical fibers in communication with the light source and the light measuring instrument and extending through the elongated body to the distal tip, wherein the one or more optical fibers are configured to pass light energy to the tissue to illuminate the tissue to excite NADH in the tissue;
a processor in communication with the light measuring instrument, the processor being programmed to:
receive NADH fluorescence data from the tissue during the delivery of ablation energy to the tissue by the ablation system; and
display an amplitude of an NADH fluorescence signal during the delivery of ablation energy, wherein the amplitude of the NADH fluorescence signal is indicative of a stability of a contact between the ablation system and the tissue.
15. The system of claim 14 , wherein the processor is programmed to monitor the amplitude of the NADH fluorescence signal during the delivery of ablation energy to confirm that the ablation system remains in contact with the tissue.
16. The system of claim 14 , wherein the tissue is illuminated with light having a wavelength between about 300 nm and about 400 nm.
17. The system of claim 14 , wherein the processor monitors a level of a reflected light having a wavelength between about 375 nm and about 575 nm.
18. The system of claim 14 , wherein the ablation energy is selected from the group consisting of radiofrequency (RF) energy, microwave energy, electrical energy, electromagnetic energy, cryoenergy, laser energy, ultrasound energy, acoustic energy, chemical energy, thermal energy, electroporation energy and combinations thereof.
19. The system of claim 14 , wherein the processor is programmed to determine a normalized magnitude of the amplitude of the NADH fluorescence signal and to display variations in a magnitude of the amplitude of the NADH fluorescence signal to the normalized magnitude of the amplitude of the NADH fluorescence signal.
20. The system of claim 14 , wherein the variations in magnitude are used to determine stability of contact between the distal tip and the tissue.
21. The system of claim 14 , further comprising a catheter comprising a catheter body; an ablation device in communication with the ablation system; and one or more optical fibers extending through the catheter body into the illumination cavity of the distal tip, the one or more optical fibers being in communication with a light source and a light measuring instrument to illuminate the tissue and to relay light energy reflected from the tissue to the light measuring instrument.