Granted Patent
B2
US 12,065,456 · App. 16/881,272 · Granted Aug 20, 2024
Boron-containing pharmacophore
Inventors:
Ronald T. Raines (Cambridge, MA); Ian William Windsor (Cambridge, MA); Brian James Graham (Belmont, MA)
Assignee:
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
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Abstract
Provided herein are boron-containing compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders.
Claims (9)
1. A compound of Formula Ia:
or a pharmaceutically acceptable salt thereof;
wherein
B is boron; and
W is absent or C(R 3 ) 2 ; and
R 3 is independently, at each occurrence, selected from the group consisting of H, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 3 -C 10 cycloalkyl, and C 3 -C 10 heterocycloalkyl.
2. The compound of claim 1 , wherein W is absent.
3. The compound of claim 1 , wherein W is CH 2 .
4. The compound of claim 1 , wherein W is C(R 3 ) 2 .
Assignments (1)
CONFIRMATORY LICENSE
Recorded Oct 2, 2023
From: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065091/0451 →
Continuity (2)
Provisional Application
62878560
· Jul 25, 2019