Solid solution compositions and use in cardiovascular disease
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
1. A solid solution pharmaceutical composition comprising:
a) a peroxisome proliferator-activator receptor gamma (PPAR-γ) agonist;
b) one or more pharmaceutically-acceptable hard fats comprising one or more glycerolipids, the one or more pharmaceutically-acceptable hard fats in an amount of at least 30% by weight of the pharmaceutical composition;
c) one or more pharmaceutically-acceptable liquid lipids comprising one or more partially hydrolyzed fats, the one or more pharmaceutically-acceptable liquid lipids in an amount of less than 45% by weight of the pharmaceutical composition, and
wherein the solid solution pharmaceutical composition is formulated to be a solid at a temperature of about 15° C. or lower and has a melting point of 30° C. or higher.
2. The solid solution pharmaceutical composition according to claim 1 , wherein the PPAR-γ agonist is about 10% to about 40% by weight of the pharmaceutical composition.
3. The solid solution pharmaceutical composition according to claim 2 , wherein the PPAR-γ agonist is about 15% to about 35% by weight of the pharmaceutical composition.
4. The solid solution pharmaceutical composition according to claim 3 , wherein the PPAR-γ agonist is in an amount from about 20% to about 30% by weight of the pharmaceutical composition.
5. The solid solution pharmaceutical composition according to claim 1 , wherein the PPAR-γ agonist comprises a non-steroidal anti-inflammatory drug (NSAID), a fibrate, a thiazolidinedione, or a combination thereof.
6. The solid solution pharmaceutical composition according to claim 5 , wherein the NSAID comprises a non-selective cyclooxygenase inhibitor, a selective cyclooxygenase 1 inhibitor, a selective cyclooxygenase 2 inhibitor or any combination thereof.
7. The solid solution pharmaceutical composition according to claim 5 , wherein the NSAID comprises a salicylate derivative NSAID, a p-amino phenol derivative NSAID, a propionic acid derivative NSAID, an acetic acid derivative NSAID, an enolic acid derivative NSAID, a fenamic acid derivative NSAID or a combination thereof.
8. The solid solution pharmaceutical composition according to claim 7 , wherein the propionic acid derivative NSAID comprises a pharmaceutically-acceptable form of an Alminoprofen, a Benoxaprofen, a Dexketoprofen, a Fenoprofen, a Flurbiprofen, an Ibuprofen, an Indoprofen, a Ketoprofen, a Loxoprofen, a Naproxen, an Oxaprozin, a Pranoprofen, or a Suprofen.
9. The solid solution pharmaceutical composition a according to claim 5 , wherein the fibrate comprises Bezafibrate, Ciprofibrate, Clofibrate, Gemfibrozil, Fenofibrate, or a combination thereof.
10. The solid solution pharmaceutical composition according to claim 1 , wherein the amount of the one or more pharmaceutically-acceptable hard fats is at least 35% by weight of the pharmaceutical composition.
11. The solid solution pharmaceutical composition according to claim 1 , wherein the amount of the one or more pharmaceutically-acceptable hard fats is about 20% to about 50% by weight of the pharmaceutical composition.
12. The solid solution pharmaceutical composition according to claim 11 , wherein the amount of the one or more pharmaceutically-acceptable hard fats is about 30% to about 50% by weight of the pharmaceutical composition.
13. The solid solution pharmaceutical composition according to claim 12 , wherein the amount of the one or more pharmaceutically-acceptable hard fats is about 35% to about 45% by weight of the pharmaceutical composition.
14. The solid solution pharmaceutical composition according to claim 1 , wherein the one or more pharmaceutically-acceptable hard fats have a melting point of about 40° C. to about 46° C.
15. The solid solution pharmaceutical composition according to claim 14 , wherein the one or more pharmaceutically-acceptable hard fats comprises a mixture of saturated C 10 -C 18 triglycerides having a melting point of between 41° C. to 45° C.
16. The solid solution pharmaceutical composition according to claim 1 , wherein the amount of the one or more pharmaceutically-acceptable liquid lipids is less than 40% by weight of the pharmaceutical composition.
17. The solid solution pharmaceutical composition according to claim 1 , wherein the amount of the one or more pharmaceutically-acceptable liquid lipids is about 10% to about 30% by weight of the pharmaceutical composition.
18. The solid solution pharmaceutical composition according to claim 17 , wherein the amount of the one or more pharmaceutically-acceptable liquid lipids is about 15% to about 25% by weight of the pharmaceutical composition.
19. The solid solution pharmaceutical composition according to claim 1 , wherein the mixture of one or more partially hydrolyzed fats comprises a mixture of one or more monoglycerides, one or more diglycerides, and one or more triglycerides.
20. The solid solution pharmaceutical composition according to claim 19 , wherein the one or more monoglycerides comprise glyceryl monolinoleate.