Method for treatment of cellular senescence
The present invention provides an alcohol extract of Ajuga taiwanensis Nakai ex Murata exhibits significant effects on inhibiting the senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. Moreover, the alcohol extract of A. taiwanensis is able to suppress the expression of the cofilin-1, a protein involved in actin dynamics and cell morphology and found to be increased in senescent cells. Suppression effect of cell senescence by this herb extract is more efficient in mild concentration without over-inhibition of cell viability and growth.
1. A method for inhibiting senescence of human dermal fibroblasts comprising administering an effective amount of an anti-aging composition comprising an alcohol extract of Ajuga taiwanensis , as an anti-aging agent, wherein the alcohol extract comprises 8-O-acetylharpagide, to a subject need thereof.
2. The method of claim 1 , wherein the anti-aging composition suppresses the expression of cofilin-1.
3. The method of claim 1 , wherein the anti-aging composition suppresses the expression of p53, p27, ROS, or a combination thereof.
4. The method of claim 1 , wherein the anti-aging composition increases the expression of SIRT1.