Compositions comprising quillaja extract and methods of preparations and use thereof

1. A composition comprising quillaja extract and at least one active ingredient, wherein the weight ratio of the quillaja extract to the active ingredient is from 12:75 to 75:25 or from 25:75 to 75:25.

2. The composition of claim 1 , wherein the active ingredient is lipid soluble.

3. The composition of claim 1 , wherein the active ingredient is selected from the group consisting of a nutritional supplement, a dietary ingredient, a medicine, and a food additive.

4. The composition of claim 3 , wherein the nutritional supplement or dietary ingredient is a quinone, a pyrroloquinoline quinone (PQQ), a cannabinoid, a curcuma isolate, berberine, diindolylmethane (DIM), a phenolic, a lipid-soluble vitamin, a symmetrical carotenoids, an omega-3 fatty acid, a terpenoid, or any combination thereof.

5. The composition of claim 3 , wherein the nutritional supplement or dietary ingredient is CoQ10, reduced CoQ10, oxidized CoQ10, vitamin K-2, cannabidiol, tetrahydrocannabinol, tumerone, curcumene, xanthorrhizol, curcumin, berberine, diindolylmethane (DIM), resveratrol, quercetin, Vitamin A, Vitamin D, Vitamin E, Vitamin K, beta-carotene, zeaxanthin, lycopene, astaxanthin, an omega-3 fatty acid, a mono-terpenoid, a di-terpenoid, a tri-terpenoid, a sesqui-terpenoid, or any combination thereof.

6. The composition of claim 1 , wherein the active ingredient is CoQ10.

7. The composition of claim 6 , wherein the CoQ10 is ubiquinol, ubiquinone, or a mixture of ubiquinol and ubiquinone.

8. The composition of claim 1 , wherein the composition is in a form of soft capsule, hard capsule, tablet, gel capsule, softgel, 2-piece liquid-filled capsule, bar, confectionary, chocolate, powder, oral suspension, pill, hard-shell, truffle, ganache, truffle ganache, gum, chewable form, an effervescent packet or pouch, an eye drop, or an aerosol spray.

9. The composition of claim 1 , wherein the quillaja extract contains about 10% to about 40% or about 20% to about 30% of quillaja saponin by weight.

10. The composition of claim 1 , wherein the composition further comprises at least one triglyceride, at least one phospholipid, or a combination thereof.

11. The composition of claim 10 , wherein the triglyceride is a medium-chain triglyceride (MCT) or wherein the phospholipid is a lecithin.

12. A method of increasing bioaccessibility and/or bioavailability of an active ingredient in a subject in need thereof, the method comprising administering a therapeutically effective amount of the composition of claim 1 to the subject thereby increasing the bioaccessibility and/or bioavailability of the active ingredient in the subject.

13. The method of claim 12 , wherein the bioaccessibility of the active ingredient increases by about 200%.

14. The method of claim 13 , wherein the active ingredient is CoQ10, vitamin K-2, vitamin E, resveratrol, or quercetin.

15. A method of preparing a powder comprising the composition of claim 1 , the method comprising drying a solution comprising the quillaja extract and the at least one active ingredient to form a dried solid and grinding the solid to form a powder comprising the quillaja extract and the at least one active ingredient.

16. The method of claim 15 , wherein the method comprises:

a. grinding the at least one active ingredient to form an at least one active ingredient powder;

b. mixing quillaja extract with water to form the quillaja extract solution;

c. mixing the at least one active ingredient powder with quillaja extract solution to form a mixture comprising the at least one active ingredient powder and the quillaja extract;

d. drying the mixture comprising the at least one active ingredient powder and the quillaja extract by stirring or by spray drying to form a dried solid comprising the least one active ingredient powder and the quillaja extract; and

e. grinding the solid comprising the at least one active ingredient powder and the quillaja extract to form the powder comprising quillaja extract and the at least one active ingredient.

17. The composition of claim 1 , wherein the quillaja extract comprises 10% to 40% or 20% to 30% of quillaja saponin by weight.