Compact auto-injector
A novel single use auto-injector for delivering a fixed amount of medicament is described. The auto-injector may include a sealed housing rotatably held in a cover. Once the auto-injector is positioned at the injection location, the user can transition the housing from a locked to an armed position. The user can then compress the sealed housing into the cover, triggering activation mechanisms that initiate the injection. A first activation mechanism engages an interlock to prevent reuse of the auto-injector. A second activation mechanism straightens and extends a curved needle to a set the exposed needle length. A third activation mechanism pierces a sealed reservoir allowing the medicament to be forced through the injection needle. Following the injection, the auto-injector expands and interlocks, retracting the needle into the auto-injector and preventing reuse.
1. A component for a compact auto-injector device for delivering a medicament dose to a user, the component comprising:
a medicament reservoir containing the medicament dose and comprising a seal;
a first sterile chamber comprising a first protective barrier, wherein the first sterile chamber contains a distal end of a dispensing needle and is located proximate to the medicament reservoir, and wherein the dispensing needle is configured to puncture the first protective barrier and the seal of the medicament reservoir to fluidically couple the medicament reservoir with the dispensing needle; and
a second sterile chamber comprising a second protective barrier, wherein the second sterile chamber is located remotely and non-contiguously with the first sterile chamber, and wherein the second sterile chamber contains a distal end of an injection needle fluidically coupled with the dispensing needle.
2. The compact auto-injector of claim 1 , wherein the first sterile chamber further comprises a dispensing needle retainer.
3. The compact auto-injector of claim 2 , wherein the dispensing needle is coupled to the dispensing needle retainer such that translation of the dispensing needle retainer causes translation of the dispensing needle.
4. The compact auto-injector of claim 2 , wherein the seal comprises a plunger adapted to translate in a translation direction within the medicament reservoir to dispense the medicament dose.
5. The compact auto-injector of claim 4 , wherein the dispensing needle is further adapted to puncture the plunger to fluidically couple the medicament reservoir with the dispensing needle.
6. The compact auto-injector of claim 4 , wherein the plunger is adapted to cause the medicament dose to flow out of the medicament reservoir through the dispensing needle in a direction opposite of the translation direction.
7. The compact auto-injector of claim 1 , further comprising a tube linking a proximal end of the dispensing needle and a proximal end of the injection needle, thereby fluidically coupling the dispending needle and the injection needle.
8. The compact auto-injector of claim 7 , wherein the injection needle comprises a hollow interior adapted to deliver the medicament dose into the user.
9. The compact auto-injector of claim 7 , wherein at least a portion of an exterior of the tube is disposed outside of at least one of the first sterile chamber or the second sterile chamber.
10. The compact auto-injector of claim 7 , wherein an interior of the tube comprises a sterile environment.
11. The compact auto-injector of claim 1 , wherein the medicament is disposed outside of at least one of the first sterile chamber or the second sterile chamber.
12. The compact auto-injector of claim 11 , wherein the medicament is disposed outside of both the first sterile chamber and the second sterile chamber.
13. The compact auto-injector of claim 1 , wherein the second sterile chamber further comprises an additional second protective barrier, wherein the injection needle is adapted to puncture the additional second protective barrier to access a tissue surface of the user.
14. The compact auto-injector of claim 1 , wherein the second sterile chamber further comprises an additional second protective barrier, wherein the additional second protective barrier is adapted to be removed such that the injection needle can access a tissue surface of the user.
15. The compact auto-injector of claim 14 , wherein the additional second protective barrier is adapted to be removed by the user.
16. A method of manufacturing a component for a compact auto-injector device for delivering a medicament dose to a user, the method comprising the steps of:
forming a medicament reservoir adapted to contain the medicament dose and comprising a seal;
forming a first sterile chamber comprising a first protective barrier, wherein the first sterile chamber contains a distal end of a dispensing needle and is located proximate to the medicament reservoir, and wherein the dispensing needle is configured to puncture the first protective barrier and the seal of the medicament reservoir to fluidically couple the medicament reservoir with the dispensing needle; and
forming a second sterile chamber comprising a second protective barrier, wherein the second sterile chamber is located remotely and non-contiguously with the first sterile chamber, and wherein the second sterile chamber contains a distal end of an injection needle fluidically coupled with the dispensing needle.
17. The method of claim 16 , wherein the first sterile chamber further comprises a dispensing needle retainer.
18. The method of claim 17 , further comprising coupling the dispensing needle to the dispensing needle retainer such that translation of the dispensing needle retainer causes translation of the dispensing needle.
19. A method of using a compact auto-injector device for delivering a medicament dose to a user, the method comprising the steps of:
obtaining an auto-injector device comprising:
a medicament reservoir containing the medicament dose and comprising a seal;
a first sterile chamber comprising a first protective barrier, wherein the first sterile chamber contains a distal end of a dispensing needle and is located proximate to the medicament reservoir, and wherein the dispensing needle is configured to puncture the first protective barrier and the seal of the medicament reservoir to fluidically couple the medicament reservoir with the dispensing needle; and
a second sterile chamber comprising a second protective barrier, wherein the second sterile chamber is located remotely and non-contiguously with the first sterile chamber, and wherein the second sterile chamber contains a distal end of an injection needle fluidically coupled with the dispensing needle;
disposing the compact auto-injector on a tissue surface of the user; and
firing the compact auto-injector such that the injection needle is inserted into the tissue surface and the medicament dose is delivered therethrough to the user.
20. The method of claim 19 , wherein the first sterile chamber further comprises a dispensing needle retainer.