Composition for reducing cancer cachexia or weight loss caused by anticancer drug therapy or radiation therapy comprising ginseng extract having increased ginsenoside Rg3 and Rh2
The present invention relates to a composition for preventing and treating cancer-related fatigue, characterized by containing a new processed ginseng powder or a new processed ginseng extract having an increased amount of a ginsenoside constituent, which was previously minute, by preparing a saponin-decomposing enzyme and subsequently using hydrolysis by the prepared saponin-decomposing enzyme and an organic acid. The composition according to the present invention can be very effectively used for preventing and treating cancer-related fatigue, the most destructive and universal side effect, which is caused by cancer itself or occurs in association with the treatment of cancer.
1. A composition for reducing cancer cachexia or weight loss caused by anticancer drug therapy or radiation therapy, comprising a ginseng extract having increased contents of ginsenosides Rg3 and Rh2, wherein the ginseng extract contains ginsenoside Rh2 in a content of 12-30 wt % and ginsenoside Rg3 in a contents of 18-30 wt %.
2. The composition of claim 1 , wherein the ginseng extract contains ginsenoside Rh2 in a content of 12-20 wt % and ginsenoside Rg3 in a contents of 18-20 wt %.
3. The composition of claim 1 , wherein the ginseng extract having increased contents of ginsenosides Rg3 and Rh2 is prepared by:
(a) inoculating an Aspergillus niger strain into a medium containing a ginseng powder and bran;
(b) culturing the strain in step (a) to produce a cultured material;
(c) purifying the cultured material in step (b) through an ultrafiltration membrane to produce a purified material;
(d) separating an enzyme from the purified material in step (c);
(e) adding the enzyme in step (d) to a ginseng powder, a red ginseng powder, a ginseng extract, or a red ginseng extract;
(f) fermenting the material after the addition in step (e) to produce a fermented material;
(g) separating the fermented material in step (f) to obtain a supernatant;
(h) concentrating the supernatant in step (g);
(i) reacting the concentrated material in step (h) with at least one organic acid selected from the group consisting of acetic acid, lactic acid, citric acid, malic acid, and tartaric acid to produce a reacted material; and
(j) neutralizing, filtering, purifying, concentrating, and drying the reacted material in step (i) to obtain the ginseng extract having increased contents of ginsenosides Rg3 and Rh2.
4. The composition of claim 1 , wherein the composition is in an orally administrable form.
5. The composition of claim 1 , wherein the ginseng extract is in powder form.
6. The composition of claim 1 , wherein the ginseng extract contains 12 wt % Rh2 and 18 wt % Rg3.
7. The composition of claim 1 , wherein an anticancer drug in the anticancer drug therapy includes cisplatin, carboplatin, paraplatin, oxaliplatin, nedaplatin, doxorubicin, taxol, docetaxel, tamoxifen, camtobell, adrucil, glivec, etoposide, zometa, oncovin, lupron, gemzar, 5-fluorouracil, and leucovorin.
8. The composition of claim 1 , wherein a content of the ginseng extract is 0.1 to 1000 parts by weight on the basis of 1 part by weight an anticancer drug in the anticancer drug therapy.