Manuka honey microneedle
A device, comprising a base, and a plurality of microneedles attached to the base, wherein the microneedles comprise dehydrated honey having water content of less than 5% by weight. The dehydrated honey can be a Manuka dehydrated honey. Also disclosed are methods of fabricating and using the disclosed device.
1. A device, comprising a base, and a plurality of microneedles attached to the base, wherein:
the microneedles comprise dehydrated honey having water content of not greater than 1% by weight; and the honey is dehydrated by vacuum treatment.
2. The device of claim 1 , wherein the base comprises dehydrated honey having water content of less than 1% by weight.
3. The device of claim 1 , wherein the dehydrated honey has water content not greater than 0.5%.
4. The device of claim 1 , wherein the microneedles further include a water-soluble polymer material, wherein the polymer material is mixed with the dehydrated honey.
5. The device of claim 1 , wherein the microneedles include a scaffold material, wherein the scaffold material is coated with the dehydrated honey.
6. The device of claim 1 , wherein the base is composed of the dehydrated honey.
7. The device of claim 1 , wherein the device includes at least one additional active pharmaceutical ingredient (API).
8. The device of claim 7 , wherein the additional API is selected from a phage, an antiviral agent, an antifungal agent, an anti-parasitic agent, an antibacterial agent, a chemotherapeutic agent, an antibody, a cytokine, a growth factor, hormone, a vaccine, a nucleic acid, a nucleic acid modifying agent, a nutraceutical agent, an anesthetic, a sedative, or a narcotic-blocking or narcotic-reversing agent.
9. The device of claim 7 , wherein the additional API is a peptide or a protein.
10. The device of claim 1 , further including a substrate layer disposed on the base.
11. The device of claim 1 , wherein the dehydrated honey is a dehydrated Manuka honey.