Granted Patent
B2
US 11,566,046 · App. 16/894,036 · Granted Jan 31, 2023
CBX8 chromdomain inhibitors and the uses thereof
Inventors:
Casey J. Krusemark (West Lafayette, IN); Emily C. Dykhuizen (West Lafayette, IN); Sijie Wang (Lafayette, IN)
Assignee:
Purdue Research Foundation
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Abstract
The present invention relates to series of peptidomimetic compounds selectively targeting CBX8 of polycomb chromobox protein homolog proteins. Pharmaceutical compositions of those compounds and methods of using them in the treatment of diseases involved CBX8 pharmacology, including various cancers and leukemia, by administering therapeutically effective amounts of such compound alone or together with other therapeutics, are within the scope of this disclosure.
Claims (1)
1. A compound having a formula selected from the group consisting of:
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 7, 2023
From: KRUSEMARK, CASEY JOHN; DYKHUIZEN, EMILY C; WANG, SIJIE
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 062617/0532 →
CONFIRMATORY LICENSE
Recorded Aug 17, 2020
From: PURDUE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 053507/0975 →
Continuity (2)
Provisional Application
62858606
· Jun 7, 2019