Fosnetupitant chloride hydrochloride having improved stability
Fosnetupitant chloride hydrochloride having improved stability, characterized by the following chemical structure:
1. Fosnetupitant chloride hydrochloride having the following formula:
wherein the fosnetupitant chloride hydrochloride comprises less than 0.7% degradants via mass degradation under air and ambient conditions for a period of 80 days.
2. The fosnetupitant chloride hydrochloride of claim 1 , wherein the degradants comprise netupitant.
3. A pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and fosnetupitant chloride hydrochloride having the following formula:
wherein the fosnetupitant chloride hydrochloride comprises less than 0.7% degradants via mass degradation under air and ambient conditions for a period of 80 days.
4. The pharmaceutical composition of claim 3 , wherein the degradants in the fosnetupitant chloride hydrochloride comprise netupitant.
5. An injectable pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and fosnetupitant chloride hydrochloride having the following formula:
wherein the fosnetupitant chloride hydrochloride comprises less than 0.7% degradants via mass degradation under air and ambient conditions for a period of 80 days.
6. The injectable pharmaceutical composition of claim 5 , wherein the degradants in the fosnetupitant chloride hydrochloride comprise netupitant.
7. Fosnetupitant chloride hydrochloride having the following formula:
wherein the fosnetupitant chloride hydrochloride is in the form of an anhydrate; and
wherein the fosnetupitant chloride hydrochloride comprises less than 0.7% degradants via mass degradation under air and ambient conditions for a period of 80 days.
8. The fosnetupitant chloride hydrochloride of claim 7 , wherein the degradants comprise netupitant.
9. A pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and fosnetupitant chloride hydrochloride having the following formula:
wherein the fosnetupitant chloride hydrochloride is in the form of an anhydrate; and
wherein the fosnetupitant chloride hydrochloride comprises less than 0.7% degradants via mass degradation under air and ambient conditions for a period of 80 days.
10. The pharmaceutical composition of claim 9 , wherein the degradants in the fosnetupitant chloride hydrochloride comprise netupitant.
11. An injectable pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and fosnetupitant chloride hydrochloride having the following formula:
wherein the fosnetupitant chloride hydrochloride is in the form of an anhydrate; and
wherein the fosnetupitant chloride hydrochloride comprises less than 0.7% degradants via mass degradation under air and ambient conditions for a period of 80 days.
12. The injectable pharmaceutical composition of claim 11 , wherein the degradants in the fosnetupitant chloride hydrochloride comprise netupitant.