Methods and Compositions to Inhibit Dependence on Opioids
The present invention provides a method of inhibiting dependence to an opioid by a human subject in need thereof. The method comprises administering an effective amount of a pharmaceutical composition to the subject during opioid therapy. The pharmaceutical composition comprises a) a non-steroidal anti-inflammatory drug (NSAID); and b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof.
1 . A method of inhibiting dependence to an opioid by a human subject in need thereof, comprising:
administering an effective amount of a pharmaceutical composition to the subject during opioid therapy, wherein the pharmaceutical composition comprises:
a) a non-steroidal anti-inflammatory drug (NSAID); and
b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof;
wherein dependence to an opioid is inhibited in the human subject.
2 . The method of claim 1 wherein the NSAID is selected from the group consisting of:
aspirin, ibuprofen, naproxen, diclofenac, diflunisal, etodolac, indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone, oxaprozin, piroxicam, salsalate, sulindac, and tolmetin.
3 . The method of claim 1 wherein the NSAID is ibuprofen and the co-agent is fexofenadine.
4 . The method of claim 1 wherein the amount of ibuprofen is about 150 mg to about 900 mg, and the amount of fexofenadine is about 60 mg to about 180 mg.
5 . The method of claim 1 wherein the ibuprofen and the fexofenadine is combined in one unit dose.
6 . The method of claim 1 wherein the ibuprofen and the fexofenadine is in the form of a tablet, lozenge or chewing gum.
7 . The method of claim 1 wherein the NSAID is ibuprofen and the co-agent is ketotifen.
8 . The method of claim 1 wherein the amount of ibuprofen is about 1200 mg to about 1600 mg, and the amount of ketotifen is about 0.5 mg to about 3 mg.
9 . The method of claim 1 wherein the daily dose of ibuprofen is about 2400 mg to about 3200 mg, and the daily dose of ketotifen is about 2 mg.
10 . The method of claim 9 wherein the ibuprofen and the ketotifen is combined in one unit dose.
11 . The method of claim 10 wherein the ibuprofen and the ketotifen is in the form of a tablet, lozenge or chewing gum.
12 . A method of inhibiting dependence to an opioid by a human subject in need thereof, comprising:
administering to the subject an effective amount of a pharmaceutical composition during an opioid withdrawal period, wherein the pharmaceutical composition consists essentially of:
a) about 1200 mg to about 1600 mg of ibuprofen, and
b) about 0.5 mg to about 3 mg ketotifen,
wherein dependence to an opioid is inhibited in the human subject.
13 . The method of claim 12 wherein the daily dose of ibuprofen is about 2400 mg to about 3200 mg, and the daily dose of ketotifen is about 2 mg.
14 . The method of claim 12 wherein the ibuprofen and the ketotifen are combined in one unit dose.
15 . The method of claim 12 wherein the ibuprofen and the ketotifen are in the form of a tablet, lozenge or chewing gum.
16 . A pharmaceutical composition comprising a) an NSAID, and/or a salt thereof; and b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine salts thereof and combinations thereof.
17 . The pharmaceutical composition of claim 16 wherein the NSAID is selected from the group consisting of: aspirin, ibuprofen, naproxen, diclofenac, diflunisal, etodolac, indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone, oxaprozin, piroxicam, salsalate, sulindac, and tolmetin.
18 . The pharmaceutical composition of claim 17 wherein the amount of ibuprofen is about 2400 mg to about 3200 mg, and the amount of ketotifen is about 2 mg.
19 . The pharmaceutical composition of claim 18 wherein the ibuprofen and the ketotifen is combined in one unit dose.
20 . The pharmaceutical composition of claim 19 wherein the ibuprofen and the ketotifen is in the form of a tablet, lozenge or chewing gum.