Wound care device having dynamic bioactive nanofiber scaffolding
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.
1. A wound care device, comprising:
a porous, pliable and formable support matrix comprising a plurality of overlapping and entangled solid, polymer-free bioactive, resorbable ceramic fibers, each respective fiber having a diameter ranging from about 5 nanometers to about 100 micrometers;
a plurality of pores distributed throughout the support matrix; and
a plurality of bioactive, resorbable glass or ceramic beads distributed throughout the support matrix;
wherein the wound care device is configured to be sufficiently chemically durable to reduce or stop blood loss from the wound.
2. The wound care device of claim 1 , wherein the beads contribute about 60 weight percent and the fibers contribute about 40 weight percent of the support matrix,
further wherein the support matrix has a bulk density of greater than about 0.1 g/cc for blood treatment applications.
3. The wound care device of claim 1 , wherein the beads contribute about 90 weight percent and the fibers contribute about 10 weight percent of the support matrix,
further wherein the support matrix has a bulk density of greater than about 0.5 g/cc for blood treatment applications.
4. The wound care device of claim 1 , wherein the fibers are composed of a material selected from the group including calcium phosphate, hydroxyapatite, bioactive glass and combinations thereof.
5. The wound care device of claim 1 , wherein the beads are solid and wherein the beads have the same composition as the fibers.
6. The wound care device of claim 1 , further including a medicine, a nutritive supplement, an antibiotic, an antiviral, a vitamin, or a combination thereof.
7. The wound care device of claim 1 , wherein at least some of the respective beads are fused to at least one respective fiber.
8. The wound care device of claim 1 , wherein the fiber diameters are substantially between about 10 nanometers and about 10 micrometers.
9. The wound care device of claim 1 , wherein at least some of the fibers are fused together.
10. The wound care device of claim 1 , wherein the beads have diameters ranging from about 30 microns to about 3 millimeters.
11. The wound care device of claim 1 , further comprising a carrier.
12. The wound care device of claim 11 , wherein the carrier is selected from the group consisting of polaxamer, glycerol, alkaline oxide copolymers, and bone marrow aspirate.
13. The wound care device of claim 1 , wherein the fibers are randomly oriented with respect to each other.
14. The wound care device of claim 1 , wherein the fibers have varying diameters.
15. The wound care device of claim 1 , wherein at least some of the fibers are nanofibers.
16. The wound care device of claim 1 , wherein the beads have varying sizes.
17. The wound care device of claim 1 , wherein some of the fibers are fused to some of the beads.
18. The wound care device of claim 1 , wherein the fibers are interlinked to form a fibrous, self-constrained construct, some of the fibers being freely movable over other fibers of the construct.
19. The wound care device of claim 1 , further having a formed, regular shape including a sheet.