Compositions comprising urolithin compounds
The invention provides compositions comprising a medium chain triglyceride and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition.
1. A method of enhancing muscle performance comprising administering to a subject an effective amount of a composition comprising:
a) medium-chain triglyceride; wherein the medium-chain triglyceride constitutes 30-80% w/w of the composition;
b) micronized urolithin A, having a D 50 size in a range of 0.5 to 50 μm, and a D 90 size in a range of 5 to 100 μm; and
c) lecithin, wherein the lecithin constitutes 1-40% w/w of the composition;
wherein the composition is formulated for oral administration.
2. The method of claim 1 , wherein the subject suffers from age-related decline in muscle function, age-related sarcopenia, age-related muscle wasting, physical fatigue, muscle fatigue, or is frail or pre-frail.
3. The method of claim 2 , wherein the subject is frail or pre-frail.
4. The method of claim 2 , wherein the subject suffers from age-related decline in muscle function, age-related sarcopenia, age-related muscle wasting, physical fatigue, or muscle fatigue.
5. The method of claim 4 , wherein the subject suffers from age-related decline in muscle function.
6. The method of claim 4 , wherein the subject suffers from age-related sarcopenia.
7. The method of claim 4 , wherein the subject suffers from age-related muscle wasting.
8. The method of claim 4 , wherein the subject suffers from physical fatigue.
9. The method of claim 4 , wherein the subject suffers from muscle fatigue.
10. The composition of claim 1 , wherein the weight ratio between the medium-chain triglyceride component and the urolithin A is in the range of 0.5:1 to 3:1.
11. The composition of claim 1 , wherein the medium-chain triglyceride comprises caprylic acid and/or capric acid.
12. The composition of claim 11 , wherein the medium-chain triglyceride is derived from a source selected from coconut oil, palm oil, and dairy fat.
13. The composition of claim 1 , further comprising an emulsifier.
14. The composition of claim 13 , wherein the emulsifier is a source of phosphatidylcholine.
15. The composition of claim 14 , wherein the source of phosphatidylcholine is lecithin.
16. The composition of claim 1 , further comprising a stabiliser.
17. The composition of claim 16 , wherein the stabiliser is glycerol monostearate.