P38 map kinase inhibitors
Provided herein, inter alia, are p38 mitogen-activated protein kinase inhibitors and methods of treating cancer using p38 mitogen-activated protein kinase inhibitors.
1. A ribonucleic acid comprising SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, or SEQ ID NO:8.
2. The ribonucleic acid of claim 1 , comprising SEQ ID NO:2.
3. The ribonucleic acid of claim 1 , comprising SEQ ID NO:3.
4. The ribonucleic acid of claim 1 , comprising SEQ ID NO:4.
5. The ribonucleic acid of claim 1 , comprising SEQ ID NO:5.
6. The ribonucleic acid of claim 1 , wherein the ribonucleic acid is an aptamer that inhibits phosphorylation of a p38γ mitogen-activated protein kinase.
7. A pharmaceutical composition comprising the ribonucleic acid of claim 1 and a pharmaceutically acceptable carrier.
8. A method of treating cancer in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of the ribonucleic acid of claim 1 .
9. The method of claim 8 , wherein the cancer is breast cancer, prostate cancer, colon cancer, ovarian cancer, bladder cancer, lung cancer, thyroid cancer, or a head and neck squamous cell carcinoma.
10. The method of claim 8 , wherein the cancer is lymphoma.
11. The method of claim 8 , wherein the cancer is cutaneous T-cell lymphoma.
12. The method of claim 8 , wherein the cancer overexpresses p38γ mitogen-activated protein kinase.
13. A method of suppressing proliferation of a cutaneous T-cell lymphoma cell, the method comprising contacting the cutaneous T-cell lymphoma cell with an effective amount of the ribonucleic acid of claim 1 ; thereby suppressing proliferation of the cutaneous T-cell lymphoma cell.
14. A method of suppressing proliferation of a cancer cell that overexpresses p38γ mitogen-activated protein kinase, the method comprising contacting the cancer cell with an effective amount of the ribonucleic acid of claim 1 ; thereby suppressing proliferation of the cancer cell.
15. A method of inhibiting phosphorylation of a p38γ mitogen-activated protein kinase, the method comprising contacting the p38γ mitogen-activated protein kinase with an effective amount of the ribonucleic acid of claim 1 ; thereby inhibiting phosphorylation of p38γ mitogen-activated protein kinase.
16. The ribonucleic acid of claim 1 , comprising SEQ ID NO:6.
17. The ribonucleic acid of claim 1 , comprising SEQ ID NO:7.
18. The ribonucleic acid of claim 1 , comprising SEQ ID NO:8.
19. The ribonucleic acid of claim 5 , comprising SEQ ID NO:1.
20. The ribonucleic acid of claim 1 , having the sequence as set forth in SEQ ID NO:1.